Diffusion MR Tractography of the Heart

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Diffusion MR Tractography of the Heart

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Title: Diffusion MR Tractography of the Heart
Author: Wang, Ruopeng; Sosnovik, David E.; Dai, Guangping; Reese, Timothy G.; Wedeen, Van Jay

Note: Order does not necessarily reflect citation order of authors.

Citation: Sosnovik, David E., Ruopeng Wang, Guangping Dai, Timothy G. Reese, and Van Jay Wedeen. 2009. Diffusion MR tractography of the heart. Journal of Cardiovascular Magnetic Resonance 11: 47.
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Abstract: Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes have been developed, ranging from scalar measurements of mean diffusivity to a 6-dimensional imaging technique known as diffusion spectrum imaging or DSI. The properties of DSI make it particularly suited to the generation of 3-dimensional tractograms of myofiber architecture. In this article we review the physical basis of diffusion-tractography in the myocardium and the attributes of the available techniques, placing particular emphasis on DSI. The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed.
Published Version: doi:10.1186/1532-429X-11-47
Other Sources: dspace.mit.edu/openaccess-disseminate/1721.1/52532
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4725514
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