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dc.contributor.authorSosnovik, David E.
dc.contributor.authorWang, Ruopeng
dc.contributor.authorDai, Guangping
dc.contributor.authorReese, Timothy G.
dc.contributor.authorWedeen, Van Jay
dc.date.accessioned2011-02-15T05:37:47Z
dc.date.issued2009
dc.identifier.citationSosnovik, David E., Ruopeng Wang, Guangping Dai, Timothy G. Reese, and Van Jay Wedeen. 2009. Diffusion MR tractography of the heart. Journal of Cardiovascular Magnetic Resonance 11: 47.en_US
dc.identifier.issn1097-6647en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4725514
dc.description.abstractHistological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes have been developed, ranging from scalar measurements of mean diffusivity to a 6-dimensional imaging technique known as diffusion spectrum imaging or DSI. The properties of DSI make it particularly suited to the generation of 3-dimensional tractograms of myofiber architecture. In this article we review the physical basis of diffusion-tractography in the myocardium and the attributes of the available techniques, placing particular emphasis on DSI. The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1532-429X-11-47en_US
dc.relation.hasversiondspace.mit.edu/openaccess-disseminate/1721.1/52532en_US
dash.licenseLAA
dc.subjectMagnetic-resonanceen_US
dc.subjectTenson MRIen_US
dc.subjectIn-Vivoen_US
dc.subjectLaminar Structureen_US
dc.subjectCardiac Fiberen_US
dc.subjectHypertrophic Cardiomyopathyen_US
dc.subjectMyocardial Microstructureen_US
dc.subjectTIssue Architectureen_US
dc.subjectWater Diffusionen_US
dc.subjectBovine Tongueen_US
dc.titleDiffusion MR Tractography of the Hearten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Cardiovascular Magnetic Resonanceen_US
dash.depositing.authorSosnovik, David E.
dc.date.available2011-02-15T05:37:47Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dash.affiliation.otherHMS^Radiology-Massachusetts General Hospitalen_US
dc.identifier.doi10.1186/1532-429X-11-47*
dash.contributor.affiliatedWedeen, Van
dash.contributor.affiliatedReese, Timothy
dash.contributor.affiliatedDai, Guangping
dash.contributor.affiliatedSosnovik, David


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