Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols.
Yang, Bryant H.
Kopecky, David J.
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CitationMyers, Andrew G., Bryant Yang, and David Kopecky. 1996. Lithium Amidotrihydroborate, a Powerful New Reductant. Transformation of Tertiary Amides to Primary Alcohols. Tetrahedron Letters 37, no. 21: 3623-3626.
AbstractLithium amidotrihydroborate (LiH3NBH3, LAB) is a new and highly nucleophilic reducing agent that is easily prepared by deprotonation of the commercial reagent borane-ammonia complex (H3NBH3) with n-BuLi in tetrahydrofuran (THF) at 0 degrees C. LAB is found to be a superior reagent for the transformation of tertiary amides into the corresponding primary alcohols.
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