Commentary on the WHO Classification of Tumors of Lymphoid Tissues (2008): Aggressive B-cell Lymphomas
Balague Ponz, Olga
Elenitoba-Johnson, Kojo S. J.
de Leval, Laurence
de Jong, Daphne
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CitationBalague Ponz, Olga, German Ott, Robert P. Hasserjian, Kojo S. J. Elenitoba-Johnson, Laurence de Leval, and Daphne de Jong. 2009. Commentary on the WHO classification of tumors of lymphoid tissues (2008): Aggressive B-cell lymphomas. Journal of Hematopathology 2(2): 83-87.
AbstractIn the novel WHO classification 2008, the classification of aggressive B-cell lymphoma has been revised for several categories with the aim to define “clean” entities. Within large B-cell lymphoma, a few distinct clinico-pathological entities have been recognized with more clinically defined entities than pathologically defined ones. The majority of known morphological variations were not considered to merit more than classification as a variant of DLBCL, not otherwise specified. Specifically, a biological subgrouping of DLBCL on the basis of molecular (activated B-cell versus germinal center B-cell) or immunophenotypic (CD5+) features was felt to be too immature to include at this stage. The role of EBV in aggressive B-cell lymphoma has been explored in more depth with the recognition of several novel and re-defined clinico-pathological entities. Also, in these diseases, clinical definitions play a very dominant role in the WHO classification 2008.
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