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dc.contributor.authorHunt, Thomas P
dc.contributor.authorIssadore, David
dc.contributor.authorWestervelt, Robert M.
dc.date.accessioned2011-02-21T00:08:55Z
dc.date.issued2008
dc.identifier.citationHunt, Thomas, David Issadore, and Robert M. Westervelt. 2008. Integrated circuit / microfluidic chip for programmable cell and droplet manipulation with dielectrophoresis. Lab on a Chip 8(1): 81-87.en_US
dc.identifier.issn1473-0197en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4728508
dc.description.abstractWe present an integrated circuit/microfluidic chip that traps and moves individual living biological cells and chemical droplets along programmable paths using dielectrophoresis (DEP). Our chip combines the biocompatibility of microfluidics with the programmability and complexity of integrated circuits (ICs). The chip is capable of simultaneously and independently controlling the location of thousands of dielectric objects, such as cells and chemical droplets. The chip consists of an array of 128 × 256 pixels, 11 × 11 µm2 in size, controlled by built-in SRAM memory; each pixel can be energized by a radio frequency (RF) voltage of up to 5 Vpp. The IC was built in a commercial foundry and the microfluidic chamber was fabricated on its top surface at Harvard. Using this hybrid chip, we have moved yeast and mammalian cells through a microfluidic chamber at speeds up to 30 µm sec–1. Thousands of cells can be individually trapped and simultaneously positioned in controlled patterns. The chip can trap and move pL droplets of water in oil, split one droplet into two, and mix two droplets into one. Our IC/microfluidic chip provides a versatile platform to trap and move large numbers of cells and fluid droplets individually for lab-on-a-chip applications.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofdoi:10.1039/b710928hen_US
dash.licenseMETA_ONLY
dc.titleIntegrated Circuit / Microfluidic Chip for Programmable Cell and Droplet Manipulation with Dielectrophoresisen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalLab on a Chipen_US
dash.depositing.authorWestervelt, Robert M.
dash.embargo.until10000-01-01
dc.identifier.doi10.1039/b710928h*
dash.contributor.affiliatedWestervelt, Robert


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