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dc.contributor.authorChoi, Won-Il
dc.contributor.authorKwon, Kun Young
dc.contributor.authorKim, Jin Mo
dc.contributor.authorQuinn, Deborah A.
dc.contributor.authorHales, Charles Albert
dc.contributor.authorSeo, Jeong Wook
dc.date.accessioned2011-03-04T04:39:32Z
dc.date.issued2008
dc.identifier.citationChoi, Won-Il, Kun Young Kwon, Jin Mo Kim, Deborah A. Quinn, Charles A. Hales, and Jeong Wook Seo. 2008. Atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic rats. Journal of Korean Medical Science 23(3): 406-413.en_US
dc.identifier.issn1011-8934en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4737044
dc.description.abstractAtelectasis can impair arterial oxygenation and decrease lung compliance. However, the effects of atelectasis on endotoxemic lungs during ventilation have not been well studied. We hypothesized that ventilation at low volumes below functional residual capacity (FRC) would accentuate lung injury in lipopolysaccharide (LPS)-pretreated rats. LPS-pretreated rats were ventilated with room air at 85 breaths/min for 2 hr at a tidal volume of 10 mL/kg with or without thoracotomy. Positive end-expiratory pressure (PEEP) was applied to restore FRC in the thoracotomy group. While LPS or thoracotomy alone did not cause significant injury, the combination of endotoxemia and thoracotomy caused significant hypoxemia and hypercapnia. The injury was observed along with a marked accumulation of inflammatory cells in the interstitium of the lungs, predominantly comprising neutrophils and mononuclear cells. Immunohistochemistry showed increased inducible nitric oxide synthase (iNOS) expression in mononuclear cells accumulated in the interstitium in the injury group. Pretreatment with PEEP or an iNOS inhibitor (1400 W) attenuated hypoxemia, hypercapnia, and the accumulation of inflammatory cells in the lung. In conclusion, the data suggest that atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic rats through iNOS expression.en_US
dc.language.isoen_USen_US
dc.publisherThe Korean Academy of Medical Sciencesen_US
dc.relation.isversionofdoi:10.3346/jkms.2008.23.3.406en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526521/pdf/en_US
dash.licenseLAA
dc.subjectatelectasisen_US
dc.subjectfunctional residual capacityen_US
dc.subjectlung injuryen_US
dc.subjectnitric oxide synthaseen_US
dc.subjectnitric oxide synthase inhibitoren_US
dc.titleAtelectasis Induced by Thoracotomy Causes Lung Injury during Mechanical Ventilation in Endotoxemic Ratsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Korean Medical Scienceen_US
dash.depositing.authorHales, Charles Albert
dc.date.available2011-03-04T04:39:32Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dc.identifier.doi10.3346/jkms.2008.23.3.406*
dash.contributor.affiliatedHales, Charles Albert


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