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dc.contributor.authorHeard-Costa, Nancy L.
dc.contributor.authorZillikens, M. Carola
dc.contributor.authorMonda, Keri L.
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorFu, Mao
dc.contributor.authorHaritunians, Talin
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorAspelund, Thor
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorGarcia, Melissa
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorSmith, Albert V.
dc.contributor.authorMitchell, Braxton D.
dc.contributor.authorMcArdle, Patrick F.
dc.contributor.authorShuldiner, Alan R.
dc.contributor.authorBielinski, Suzette J.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBrancati, Fred
dc.contributor.authorDemerath, Ellen W.
dc.contributor.authorPankow, James S.
dc.contributor.authorArnold, Alice M.
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorGlazer, Nicole L.
dc.contributor.authorMcKnight, Barbara
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorAmin, Najaf
dc.contributor.authorCampbell, Harry
dc.contributor.authorGyllensten, Ulf
dc.contributor.authorPattaro, Cristian
dc.contributor.authorPramstaller, Peter P.
dc.contributor.authorRudan, Igor
dc.contributor.authorStruchalin, Maksim
dc.contributor.authorVitart, Veronique
dc.contributor.authorGao, Xiaoyi
dc.contributor.authorKraja, Aldi
dc.contributor.authorProvince, Michael A.
dc.contributor.authorZhang, Qunyuan
dc.contributor.authorAtwood, Larry D.
dc.contributor.authorDupuis, Josée
dc.contributor.authorJaquish, Cashell E.
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorWhite, Charles C.
dc.contributor.authorAulchenko, Yurii S.
dc.contributor.authorEstrada, Karol
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorWitteman, Jacqueline C. M.
dc.contributor.authorOostra, Ben A.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorO'Connell, Jeffrey R.
dc.contributor.authorBorecki, Ingrid B.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorCupples, L. Adrienne
dc.contributor.authorNorth, Kari E.
dc.contributor.authorHirschhorn, Joel Naom
dc.contributor.authorO'Donnell, Christopher Joseph
dc.contributor.authorHofman, Albert
dc.contributor.authorKaplan, Robert C.
dc.contributor.authorFox, Caroline
dc.contributor.authorJohansson, Asa
dc.date.accessioned2011-03-08T17:59:02Z
dc.date.issued2009
dc.identifier.citationHeard-Costa, Nancy L., M. Carola Zillikens, Keri L. Monda, Asa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, et. al. 2009. NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium. PLoS Genetics 5(6): e1000539.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4739277
dc.description.abstractCentral abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist circumference (WC). In total, three loci reached genome-wide significance. In stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role of FTO and MC4R and identified one novel locus associated with WC in the neurexin 3 gene [NRXN3 (rs10146997, p = 6.4×10^−7)]. The association with NRXN3 was confirmed in stage 2 by combining stage 1 results with those from 38,641 participants in the GIANT consortium (p = 0.009 in GIANT only, p = 5.3×10^−8 for combined analysis, n = 70,014). Mean WC increase per copy of the G allele was 0.0498 z-score units (0.65 cm). This SNP was also associated with body mass index (BMI) [p = 7.4×10^−6, 0.024 z-score units (0.10 kg/m2) per copy of the G allele] and the risk of obesity (odds ratio 1.13, 95% CI 1.07–1.19; p = 3.2×10^−5 per copy of the G allele). The NRXN3 gene has been previously implicated in addiction and reward behavior, lending further evidence that common forms of obesity may be a central nervous system-mediated disorder. Our findings establish that common variants in NRXN3 are associated with WC, BMI, and obesity.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi://10.1371/journal.pgen.1000539en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695005/pdf/en_US
dash.licenseLAA
dc.subjectgenetics and genomicsen_US
dc.subjectcomplex traitsen_US
dc.subjectnutritionen_US
dc.subjectobesityen_US
dc.titleNRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortiumen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorHirschhorn, Joel Naom
dc.date.available2011-03-08T17:59:02Z
dash.affiliation.otherHMS^Geneticsen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pgen.1000539*
dash.authorsorderedfalse
dash.contributor.affiliatedFox, Caroline
dash.contributor.affiliatedO'Donnell, Christopher
dash.contributor.affiliatedHirschhorn, Joel


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