IL-17 in Systemic Lupus Erythematosus

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IL-17 in Systemic Lupus Erythematosus

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Title: IL-17 in Systemic Lupus Erythematosus
Author: Crispín, José C.; Tsokos, George C.

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Citation: Crispín, José C., and George C. Tsokos. 2010. IL-17 in systemic lupus erythematosus. Journal of Biomedicine and Biotechnology 2010: 943254.
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Abstract: IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3+CD4−CD8− (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells.
Published Version: doi:10.1155/2010/943254
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