IL-17 in Systemic Lupus Erythematosus

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IL-17 in Systemic Lupus Erythematosus

Show simple item record Crispín, José C. Tsokos, George C. 2011-03-08T19:07:53Z 2010
dc.identifier.citation Crispín, José C., and George C. Tsokos. 2010. IL-17 in systemic lupus erythematosus. Journal of Biomedicine and Biotechnology 2010: 943254. en_US
dc.identifier.issn 1110-7243 en_US
dc.description.abstract IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3+CD4−CD8− (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells. en_US
dc.language.iso en_US en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.isversionof doi:10.1155/2010/943254 en_US
dc.relation.hasversion en_US
dash.license LAA
dc.title IL-17 in Systemic Lupus Erythematosus en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Biomedicine and Biotechnology en_US Tsokos, George C. 2011-03-08T19:07:53Z
dash.affiliation.other HMS^Medicine- Beth Israel-Deaconess en_US

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