IL-17 in Systemic Lupus Erythematosus

DSpace/Manakin Repository

IL-17 in Systemic Lupus Erythematosus

Show simple item record

dc.contributor.author Crispín, José C.
dc.contributor.author Tsokos, George C.
dc.date.accessioned 2011-03-08T19:07:53Z
dc.date.issued 2010
dc.identifier.citation Crispín, José C., and George C. Tsokos. 2010. IL-17 in systemic lupus erythematosus. Journal of Biomedicine and Biotechnology 2010: 943254. en_US
dc.identifier.issn 1110-7243 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4739309
dc.description.abstract IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3+CD4−CD8− (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells. en_US
dc.language.iso en_US en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.isversionof doi:10.1155/2010/943254 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850519/pdf/ en_US
dash.license LAA
dc.title IL-17 in Systemic Lupus Erythematosus en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Biomedicine and Biotechnology en_US
dash.depositing.author Tsokos, George C.
dc.date.available 2011-03-08T19:07:53Z
dash.affiliation.other HMS^Medicine- Beth Israel-Deaconess en_US

Files in this item

Files Size Format View
2850519.pdf 510.3Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters