Systems Engineering to Systems Biology

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Systems Engineering to Systems Biology

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Title: Systems Engineering to Systems Biology
Author: Yıldırım, Muhammed A; Vidal, Marc

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Citation: Yıldırım, Muhammed A., and Marc Vidal. 2008. Systems engineering to systems biology. Molecular Systems Biology 4: 185.
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Abstract: No abstract provided. First paragraph: The ‘bottom-up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top-down’ fashion, using a variety of network reverse engineering methods, data-driven modeling and data integration strategies. Application of a top-down approach to the quantitative biology of a small size system is however less common. In a recent publication, Mettetal et al (2008) have insightfully applied such a strategy to successfully decode critical properties of osmo-adaptation in the yeast Saccharomyces cerevisiae.
Published Version: doi:10.1038/msb.2008.22
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