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dc.contributor.authorKoh, Young-Sang
dc.contributor.authorKoo, Jung-Eun
dc.contributor.authorBiswas, Amlan
dc.contributor.authorKobayashi, Koichi S
dc.date.accessioned2011-03-23T16:59:29Z
dc.date.issued2010
dc.identifier.citationKoh, Young-Sang, Jung-Eun Koo, Amlan Biswas, and Koichi S. Kobayashi. 2010. MyD88-Dependent signaling contributes to host defense against ehrlichial infection. PLoS ONE 5(7): e11758.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4768917
dc.description.abstractThe ehrlichiae are small Gram-negative obligate intracellular bacteria in the family Anaplasmataceae. Ehrlichial infection in an accidental host may result in fatal diseases such as human monocytotropic ehrlichiosis, an emerging, tick-borne disease. Although the role of adaptive immune responses in the protection against ehrlichiosis has been well studied, the mechanism by which the innate immune system is activated is not fully understood. Using Ehrlichia muris as a model organism, we show here that MyD88-dependent signaling pathways play a pivotal role in the host defense against ehrlichial infection. Upon E. muris infection, MyD88-deficient mice had significantly impaired clearance of E. muris, as well as decreased inflammation, characterized by reduced splenomegaly and recruitment of macrophages and neutrophils. Furthermore, MyD88-deficient mice produced markedly lower levels of IL-12, which correlated well with an impaired Th1 immune response. In vitro, dendritic cells, but not macrophages, efficiently produced IL-12 upon E. muris infection through a MyD88-dependent mechanism. Therefore, MyD88-dependent signaling is required for controlling ehrlichial infection by playing an essential role in the immediate activation of the innate immune system and inflammatory cytokine production, as well as in the activation of the adaptive immune system at a later stage by providing for optimal Th1 immune responses.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0011758en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909256/pdf/en_US
dash.licenseLAA
dc.subjectimmunologyen_US
dc.subjectimmunity to infectionsen_US
dc.subjectinnate immunityen_US
dc.subjectmicrobiologyen_US
dc.titleMyD88-Dependent Signaling Contributes to Host Defense against Ehrlichial Infectionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorBiswas, Amlan
dc.date.available2011-03-23T16:59:29Z
dash.affiliation.otherHMS^Pathologyen_US
dash.affiliation.otherHMS^Pathologyen_US
dc.identifier.doi10.1371/journal.pone.0011758*
dash.contributor.affiliatedBiswas, Amlan
dash.contributor.affiliatedKobayashi, Koichi S.


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