Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein

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Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein

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dc.contributor.author Stansell, Elizabeth
dc.contributor.author Desrosiers, Ronald C.
dc.date.accessioned 2011-03-25T15:46:22Z
dc.date.issued 2010
dc.identifier.citation Stansell, Elizabeth, and Ronald C. Desrosiers. 2010. Functional contributions of carbohydrate on AIDS virus glycoprotein. Yale Journal of Biology and Medicine 83(4): 201-208. en_US
dc.identifier.issn 0044-0086 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4773992
dc.description.abstract Envelope glycoprotein spikes on the surface of the human immunodeficiency virus (HIV) are used by the virus to bind to cellular receptors to gain entry into target cells. As such, the envelope spikes are the targets of antibodies that can neutralize viral infectivity. Fifty percent or more of the mass of the viral-encoded surface glycoprotein of HIV, and of its close monkey relative simian immunodeficiency virus (SIV), is actually carbohydrate; it is one of the most heavily glycosylated proteins that can be found in mammals. It has been clearly demonstrated that one of the functions of this carbohydrate is to shield viral epitopes that would otherwise be the direct target of antibodies that could neutralize viral infection. In addition, it is now generally accepted that the carbohydrate on the viral envelope glycoprotein is recognized by multiple cellular lectins of the host lymphoreticular system, and these interactions play a role in the dissemination of virus within the host as well as the release of modulatory cytokines. Our work recently demonstrated fundamental differences in the composition of the carbohydrate on HIV type 1, the cause of the AIDS pandemic, versus the SIV in the sooty mangabey monkey, a natural host that does not develop disease from its infection. We now speculate that this fundamental difference in carbohydrate composition reflects evolutionary pressures on both virus and host. Furthermore, carbohydrate composition on the virus and genetic differences in carbohydrate-sensing proteins of the host could be critically important for the generalized lymphoid activation that characterizes the acquired immunodeficiency syndrome (AIDS). en_US
dc.language.iso en_US en_US
dc.publisher YJBM en_US
dc.relation.isversionof http://medicine.yale.edu en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002149/pdf/ en_US
dash.license LAA
dc.title Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Yale Journal of Biology and Medicine en_US
dash.depositing.author Desrosiers, Ronald C.
dc.date.available 2011-03-25T15:46:22Z
dash.affiliation.other HMS^New England Primate Research Center en_US
dash.affiliation.other HMS^Microbiology and Molecular Genetics en_US

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