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dc.contributor.authorTampakakis, Emmanouil
dc.contributor.authorPuckett, Lindsay
dc.contributor.authorTai, Melissa F.
dc.contributor.authorStewart, Cameron R.
dc.contributor.authorHickman, Suzanne E.
dc.contributor.authorMoore, Kathryn J.
dc.contributor.authorEl Khoury, Joseph
dc.contributor.authorMeans, Terry K.
dc.contributor.authorMylonakis, Eleftherios
dc.contributor.authorColvin, Richard Anthony
dc.contributor.authorSeung, Edward N.
dc.contributor.authorPukkila-Worley, Read
dc.contributor.authorCalderwood, Stephen Beaven
dc.contributor.authorHacohen, Nir
dc.contributor.authorLuster, Andrew David
dc.date.accessioned2011-03-29T16:09:49Z
dc.date.issued2009
dc.identifier.citationMeans, Terry K., Eleftherios Mylonakis, Emmanouil Tampakakis, Richard A. Colvin, Edward Seung, Lindsay Puckett, Melissa F. Tai, et al. 2009. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. Journal of Experimental Medicine 206(3): 637-653.en_US
dc.identifier.issn0022-1007en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4777436
dc.description.abstractReceptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.en_US
dc.language.isoen_USen_US
dc.publisherRockefeller University Pressen_US
dc.relation.isversionofdoi:10.1084/jem.20082109en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699123/pdf/en_US
dash.licenseLAA
dc.titleEvolutionarily Conserved Recognition and Innate Immunity to Fungal Pathogens by the Scavenger Receptors SCARF1 and CD36en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Experimental Medicineen_US
dash.depositing.authorSeung, Edward N.
dc.date.available2011-03-29T16:09:49Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dc.identifier.doi10.1084/jem.20082109*
dash.authorsorderedfalse
dash.contributor.affiliatedColvin, Richard Anthony
dash.contributor.affiliatedHacohen, Nir
dash.contributor.affiliatedPukkila-Worley, Read
dash.contributor.affiliatedMylonakis, E
dash.contributor.affiliatedLuster, Andrew
dash.contributor.affiliatedSeung, Edward N.
dash.contributor.affiliatedCalderwood, Stephen
dash.contributor.affiliatedMeans, Terry K.


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