Morphological Instability and Cancer Invasion: A 'Splashing Water Drop' Analogy

DSpace/Manakin Repository

Morphological Instability and Cancer Invasion: A 'Splashing Water Drop' Analogy

Citable link to this page

 

 
Title: Morphological Instability and Cancer Invasion: A 'Splashing Water Drop' Analogy
Author: Guiot, Caterina; Delsanto, Pier P; Deisboeck, Thomas Steve

Note: Order does not necessarily reflect citation order of authors.

Citation: Guiot, Caterina, Pier P. Delsanto, and Thomas S. Deisboeck. 2007. Morphological instability and cancer invasion: a 'splashing water drop' analogy. Theoretical Biology & Medical Modelling 4: 4.
Full Text & Related Files:
Abstract: Background: Tissue invasion, one of the hallmarks of cancer, is a major clinical problem. Recent studies suggest that the process of invasion is driven at least in part by a set of physical forces that may be susceptible to mathematical modelling which could have practical clinical value. Model and conclusion: We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea, it yields a very practical result, i.e. an index that predicts tumor invasion based on a few measurable parameters. We discuss its application in the context of experimental data and suggest potential clinical implications.
Published Version: doi://10.1186/1742-4682-4-4
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794228/pdf/
http://www.tbiomed.com/content/4/1/4
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4817360
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters