Morphological Instability and Cancer Invasion: A 'Splashing Water Drop' Analogy
Delsanto, Pier P
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CitationGuiot, Caterina, Pier P. Delsanto, and Thomas S. Deisboeck. 2007. Morphological instability and cancer invasion: a 'splashing water drop' analogy. Theoretical Biology & Medical Modelling 4: 4.
AbstractBackground: Tissue invasion, one of the hallmarks of cancer, is a major clinical problem. Recent studies suggest that the process of invasion is driven at least in part by a set of physical forces that may be susceptible to mathematical modelling which could have practical clinical value. Model and conclusion: We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea, it yields a very practical result, i.e. an index that predicts tumor invasion based on a few measurable parameters. We discuss its application in the context of experimental data and suggest potential clinical implications.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4817360
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