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dc.contributor.authorSale, Michèle M
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorPalmer, Nicholette D
dc.contributor.authorGordon, Candace J
dc.contributor.authorKeene, Keith L
dc.contributor.authorBorgerink, Hermina M
dc.contributor.authorBergman, Richard N
dc.contributor.authorTaylor, Kent D
dc.contributor.authorSaad, Mohammed F
dc.contributor.authorNorris, Jill M
dc.contributor.authorSharma, Arun J.
dc.date.accessioned2011-04-16T01:58:07Z
dc.date.issued2007
dc.identifier.citationSale, Michéle M, Fang-Chi Hsu, Nicholette D Palmer, Candace J Gordon, Keith L Keene, Hermina M Borgerink, Arun J Sharma, and et al. 2007. The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. BMC Endocrine Disorders 7: 1.en_US
dc.identifier.issn1472-6823en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4851339
dc.description.abstractBackground: Variants of uncoupling protein genes UCP1 and UCP2 have been associated with a range of traits. We wished to evaluate contributions of known UCP1 and UCP2 variants to metabolic traits in the Insulin Resistance and Atherosclerosis (IRAS) Family Study. Methods: We genotyped five promoter or coding single nucleotide polymorphisms (SNPs) in 239 African American (AA) participants and 583 Hispanic participants from San Antonio (SA) and San Luis Valley. Generalized estimating equations using a sandwich estimator of the variance and exchangeable correlation to account for familial correlation were computed for the test of genotypic association, and dominant, additive and recessive models. Tests were adjusted for age, gender and BMI (glucose homeostasis and lipid traits), or age and gender (obesity traits), and empirical P-values estimated using a gene dropping approach. Results: UCP1 A-3826G was associated with AIRg in AA (P = 0.006) and approached significance in Hispanic families (P = 0.054); and with HDL-C levels in SA families (P = 0.0004). Although UCP1 expression is reported to be restricted to adipose tissue, RT-PCR indicated that UCP1 is expressed in human pancreas and MIN-6 cells, and immunohistochemistry demonstrated co-localization of UCP1 protein with insulin in human islets. UCP2 A55V was associated with waist circumference (P = 0.045) in AA, and BMI in SA (P = 0.018); and UCP2 G-866A with waist-to-hip ratio in AA (P = 0.016). Conclusion: This study suggests a functional variant of UCP1 contributes to the variance of AIRg in an AA population; the plausibility of this unexpected association is supported by the novel finding that UCP1 is expressed in islets.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1472-6823-7-1en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852562/pdf/en_US
dash.licenseLAA
dc.titleThe Uncoupling Protein 1 Gene, UCP1, is Expressed in Mammalian Islet Cells and Associated with Acute Insulin Response to Glucose in African American Families from the IRAS Family Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Endocrine Disordersen_US
dash.depositing.authorSharma, Arun J.
dc.date.available2011-04-16T01:58:07Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1186/1472-6823-7-1*
dash.authorsorderedfalse
dash.contributor.affiliatedSharma, Arun J.


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