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dc.contributor.authorShi, Ping
dc.contributor.authorMehta, Amar J.
dc.contributor.authorHang, Jing-qing
dc.contributor.authorZhang, Hongxi
dc.contributor.authorDai, Helian
dc.contributor.authorSu, Li
dc.contributor.authorEisen, Ellen A.
dc.contributor.authorChristiani, David C.
dc.date.accessioned2011-04-22T19:27:58Z
dc.date.issued2010
dc.identifier.citationShi, Jing, Amar J. Mehta, Jing-qing Hang, Hongxi Zhang, Helian Dai, Li Su, Ellen A. Eisen, and David C. Christiani. 2010. Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin. Environmental Health Perspectives 118(11): 1620-1624.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4874478
dc.description.abstractBackground: Long-term occupational exposure to cotton dust that contains endotoxin is associated with chronic respiratory symptoms and excessive decline in forced expiratory volume in 1 sec (FEV1), but the mechanisms of endotoxin-related chronic airflow obstruction remain unclear. Objective: In the current study, we examined temporal aspects of the exposure–response relationship between airborne endotoxin exposure, longitudinal change in FEV1, and respiratory symptoms in a cohort of Chinese cotton textile workers. Methods: This prospective cohort study followed 447 cotton textile workers from 1981 to 2006.at approximately 5-year intervals. We used a generalized estimating equations approach to model FEV1 level and respiratory symptoms as a function of past exposure (cumulative exposure up to the start of the most recent 5-year survey interval) and cumulative exposure (within the most recent interval) to endotoxins, after adjusting for other covariates. Models were stratified by active versus retired work status and by years employed before the baseline survey (< 5 and ≥ 5 years). Results and conclusions: Past exposure to endotoxin was associated with reduced FEV1 level among retired cotton workers. Among all cotton workers, past exposure was more strongly associated with reduced FEV1 for those hired < 5 years before baseline than for those who were hired ≥ 5 years after baseline. Recent endotoxin exposure was significantly associated with byssinosis, chronic bronchitis, and chronic cough.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0901178en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974703/pdf/en_US
dash.licenseLAA
dc.subjectbyssinosisen_US
dc.subjectChinaen_US
dc.subjectchronic obstructive lung diseaseen_US
dc.subjectcotton textile workersen_US
dc.subjectoccupational healthen_US
dc.subjectorganic dustsen_US
dc.subjectpulmonary functionen_US
dc.titleChronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxinen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorShi, Ping
dc.date.available2011-04-22T19:27:58Z
dash.affiliation.otherHMS^Population Medicineen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.0901178*
dash.contributor.affiliatedShi, Ping
dash.contributor.affiliatedEisen, Ellen
dash.contributor.affiliatedSu, Li
dash.contributor.affiliatedChristiani, David


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