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dc.contributor.authorTamimi, Rulla May
dc.contributor.authorByrne, Celia
dc.contributor.authorBaer, Heather Joanne
dc.contributor.authorRosner, Bernie
dc.contributor.authorSchnitt, Stuart Jay
dc.contributor.authorConnolly, James Leo
dc.contributor.authorColditz, Graham A.
dc.date.accessioned2011-04-22T21:11:33Z
dc.date.issued2005
dc.identifier.citationTamimi, Rulla M, Celia Byrne, Heather J Baer, Bernie Rosner, Stuart J Schnitt, James L Connolly, and Graham A Colditz. 2005. Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case- control study. Breast Cancer Research 7(4): R555-R562.en_US
dc.identifier.issn1465-5411en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4874589
dc.description.abstractIntroduction: Alcohol consumption is a well-established risk factor for breast cancer. Some studies have suggested that the risk of breast cancer associated with alcohol consumption is greater for women with a history of benign breast disease (BBD). We hypothesized that among women with biopsy-confirmed BBD, recent alcohol consumption would increase the risk of breast cancer in women with proliferative breast disease to a greater extent than in women with nonproliferative breast disease. Methods: We conducted a nested case–control study in the Nurses' Health Study I and II. The cases (n = 282) were women diagnosed with incident breast cancer, with a prior biopsy-confirmed breast disease. The controls (n = 1,223) were participants with a previous BBD biopsy, but without a diagnosis of breast cancer. Pathologists reviewed benign breast biopsy slides in a blinded fashion and classified the BBD as nonproliferative, proliferative without atypia, or atypical hyperplasia, according to standard criteria. Results: Women with nonproliferative breast disease consuming ≥ 15 g of alcohol per day had a nonsignificant 67% increased risk of breast cancer (odds ratio = 1.67; 95% confidence interval 0.65 to 4.34) compared with nondrinkers. There was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent in women with proliferative BBD than among women with nonproliferative BBD (P for interactio n = 0.20). Conclusion: Contrary to our a priori hypothesis, there was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent among women with proliferative BBD than among women with nonproliferative BBD.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/bcr1039en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175067/pdf/en_US
dash.licenseLAA
dc.titleBenign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBreast Cancer Researchen_US
dash.depositing.authorTamimi, Rulla May
dc.date.available2011-04-22T21:11:33Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Pathologyen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dc.identifier.doi10.1186/bcr1039*
dash.contributor.affiliatedConnolly, James
dash.contributor.affiliatedBaer, Heather
dash.contributor.affiliatedTamimi, Rulla
dash.contributor.affiliatedColditz, Graham
dash.contributor.affiliatedSchnitt, Stuart


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