TLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremia

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TLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremia

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dc.contributor.author Strunk, Tobias
dc.contributor.author Power Coombs, Melanie R.
dc.contributor.author Currie, Andrew J.
dc.contributor.author Richmond, Peter
dc.contributor.author Golenbock, Douglas T.
dc.contributor.author Stoler-Barak, Liat
dc.contributor.author Gallington, Leighanne C.
dc.contributor.author Otto, Michael
dc.contributor.author Burgner, David
dc.contributor.author Levy, Ofer
dc.date.accessioned 2011-04-23T01:14:06Z
dc.date.issued 2010
dc.identifier.citation Strunk, Tobias, Melanie R. Power Coombs, Andrew J. Currie, Peter Richmond, Douglas T. Golenbock, Liat Stoler-Barak, Leighanne C. Gallington, Michael Otto, David Burgner, and Ofer Levy. 2010. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS ONE 5(4): e10111. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874770
dc.description.abstract Background: Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms. SE-derived soluble components engage TLR2; but additional signaling pathways have also been implicated, and TLR2 can play complex, at times detrimental, roles in host defense against other Staphylococcal spp. The role of TLR2 in responses of primary blood leukocytes to live SE and in clearance of SE bacteremia, the most common clinical manifestation of SE infection, is unknown. Methodology/Principal Findings: We studied TLR2-mediated recognition of live clinical SE strain 1457 employing TLR2-transfected cells, neutralizing anti-TLR antibodies and TLR2-deficient mice. TLR2 mediated SE-induced cytokine production in human embryonic kidney cells, human whole blood and murine primary macrophages, in part via recognition of a soluble TLR2 agonist. After i.v. challenge with SE, early (1 h) cytokine/chemokine production and subsequent clearance of bacteremia (24–48 h) were markedly impaired in TLR2-deficient mice. Conclusions/Significance: TLR2 mediates recognition of live SE and clearance of SE bacteremia in vivo. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0010111 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852418/pdf/ en_US
dash.license LAA
dc.subject immunology en_US
dc.subject immunity to infections en_US
dc.subject innate immunity en_US
dc.subject microbiology en_US
dc.subject infectious diseases en_US
dc.subject bacterial infections en_US
dc.title TLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremia en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Levy, Ofer
dc.date.available 2011-04-23T01:14:06Z
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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