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dc.contributor.authorStrunk, Tobias
dc.contributor.authorPower Coombs, Melanie R.
dc.contributor.authorCurrie, Andrew J.
dc.contributor.authorRichmond, Peter
dc.contributor.authorGolenbock, Douglas T.
dc.contributor.authorStoler-Barak, Liat
dc.contributor.authorGallington, Leighanne C.
dc.contributor.authorOtto, Michael
dc.contributor.authorBurgner, David
dc.contributor.authorLevy, Ofer
dc.date.accessioned2011-04-23T01:14:06Z
dc.date.issued2010
dc.identifier.citationStrunk, Tobias, Melanie R. Power Coombs, Andrew J. Currie, Peter Richmond, Douglas T. Golenbock, Liat Stoler-Barak, Leighanne C. Gallington, Michael Otto, David Burgner, and Ofer Levy. 2010. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS ONE 5(4): e10111.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4874770
dc.description.abstractBackground: Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms. SE-derived soluble components engage TLR2; but additional signaling pathways have also been implicated, and TLR2 can play complex, at times detrimental, roles in host defense against other Staphylococcal spp. The role of TLR2 in responses of primary blood leukocytes to live SE and in clearance of SE bacteremia, the most common clinical manifestation of SE infection, is unknown. Methodology/Principal Findings: We studied TLR2-mediated recognition of live clinical SE strain 1457 employing TLR2-transfected cells, neutralizing anti-TLR antibodies and TLR2-deficient mice. TLR2 mediated SE-induced cytokine production in human embryonic kidney cells, human whole blood and murine primary macrophages, in part via recognition of a soluble TLR2 agonist. After i.v. challenge with SE, early (1 h) cytokine/chemokine production and subsequent clearance of bacteremia (24–48 h) were markedly impaired in TLR2-deficient mice. Conclusions/Significance: TLR2 mediates recognition of live SE and clearance of SE bacteremia in vivo.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0010111en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852418/pdf/en_US
dash.licenseLAA
dc.subjectimmunologyen_US
dc.subjectimmunity to infectionsen_US
dc.subjectinnate immunityen_US
dc.subjectmicrobiologyen_US
dc.subjectinfectious diseasesen_US
dc.subjectbacterial infectionsen_US
dc.titleTLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremiaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorLevy, Ofer
dc.date.available2011-04-23T01:14:06Z
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0010111*
dash.contributor.affiliatedLevy, Ofer


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