dc.contributor.author | Zhao, Jin-Lu | |
dc.contributor.author | Zhang, Chun-Peng | |
dc.contributor.author | Lin, Luo-Qiang | |
dc.contributor.author | Chen, Hong-Sheng | |
dc.contributor.author | Zhang, Shu-Jun | |
dc.contributor.author | Jin, Jun-Chao | |
dc.contributor.author | Li, Le-Jing | |
dc.contributor.author | Liu, Yan | |
dc.contributor.author | Liu, Ming | |
dc.contributor.author | Li, Bin | |
dc.contributor.author | Wang, Lei | |
dc.contributor.author | Liu, Jia-Ren | |
dc.date.accessioned | 2011-04-23T01:17:19Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Liu, Yan, Ming Liu, Bin Li, Jin-Lu Zhao, Chun-Peng Zhang, Luo-Qiang Lin, Hong-Sheng Chen, et al. 2010. Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model. Nutrition & Metabolism 7: 84. | en_US |
dc.identifier.issn | 1743-7075 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874771 | |
dc.description.abstract | Background: Red raspberry possesses potent antioxidant capacity and antiproliferative activity against cancer in vitro. Methods: The objective of this study was to determine the protective effects of raspberry 80% acetone extract in a rat hepatic lesions model induced by diethylnitrosamine (DEN). Rats were treated with the red raspberry extract (0.75, 1.5 or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continuing for 20 weeks. Results: A dose-dependent inhibition by red raspberry extract of DEN-induced hepatic nodule formation which stands for hepatic lesions was observed. Corresponding hepatic nodule incidence rates were 45.0, 40.0, 25.0 and 5.0% in positive control, low, middle and high groups, respectively (P < 0.01 or 0.05). Gross findings, histopathological and ultrastructural evaluations of hepatic lesion were performed on 9, 8, 5 and 1 hepatic nodule in positive control, low, middle and high doses of groups, respectively, identified in rats from the respective groups of 20. A decreasing trend of proportions of hepatocellular carcinoma masses accompanied the increasing doses of red raspberry extract. Conclusions: These findings demonstrate that the potent capacity of red raspberry diet could not only suppress DEN-induced hepatic lesions in rats, but also reduce the definite diagnostic features of neoplasm. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.isversionof | doi:10.1186/1743-7075-7-84 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999596/pdf/ | en_US |
dash.license | LAA | |
dc.title | Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Nutrition & Metabolism | en_US |
dash.depositing.author | Liu, Jia-Ren | |
dc.date.available | 2011-04-23T01:17:19Z | |
dash.affiliation.other | HMS^Anaesthesia-Children's Hospital | en_US |
dc.identifier.doi | 10.1186/1743-7075-7-84 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Liu, Jia-Ren | |