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dc.contributor.authorZhao, Jin-Lu
dc.contributor.authorZhang, Chun-Peng
dc.contributor.authorLin, Luo-Qiang
dc.contributor.authorChen, Hong-Sheng
dc.contributor.authorZhang, Shu-Jun
dc.contributor.authorJin, Jun-Chao
dc.contributor.authorLi, Le-Jing
dc.contributor.authorLiu, Yan
dc.contributor.authorLiu, Ming
dc.contributor.authorLi, Bin
dc.contributor.authorWang, Lei
dc.contributor.authorLiu, Jia-Ren
dc.date.accessioned2011-04-23T01:17:19Z
dc.date.issued2010
dc.identifier.citationLiu, Yan, Ming Liu, Bin Li, Jin-Lu Zhao, Chun-Peng Zhang, Luo-Qiang Lin, Hong-Sheng Chen, et al. 2010. Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model. Nutrition & Metabolism 7: 84.en_US
dc.identifier.issn1743-7075en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4874771
dc.description.abstractBackground: Red raspberry possesses potent antioxidant capacity and antiproliferative activity against cancer in vitro. Methods: The objective of this study was to determine the protective effects of raspberry 80% acetone extract in a rat hepatic lesions model induced by diethylnitrosamine (DEN). Rats were treated with the red raspberry extract (0.75, 1.5 or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continuing for 20 weeks. Results: A dose-dependent inhibition by red raspberry extract of DEN-induced hepatic nodule formation which stands for hepatic lesions was observed. Corresponding hepatic nodule incidence rates were 45.0, 40.0, 25.0 and 5.0% in positive control, low, middle and high groups, respectively (P < 0.01 or 0.05). Gross findings, histopathological and ultrastructural evaluations of hepatic lesion were performed on 9, 8, 5 and 1 hepatic nodule in positive control, low, middle and high doses of groups, respectively, identified in rats from the respective groups of 20. A decreasing trend of proportions of hepatocellular carcinoma masses accompanied the increasing doses of red raspberry extract. Conclusions: These findings demonstrate that the potent capacity of red raspberry diet could not only suppress DEN-induced hepatic lesions in rats, but also reduce the definite diagnostic features of neoplasm.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1743-7075-7-84en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999596/pdf/en_US
dash.licenseLAA
dc.titleFresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat modelen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNutrition & Metabolismen_US
dash.depositing.authorLiu, Jia-Ren
dc.date.available2011-04-23T01:17:19Z
dash.affiliation.otherHMS^Anaesthesia-Children's Hospitalen_US
dc.identifier.doi10.1186/1743-7075-7-84*
dash.authorsorderedfalse
dash.contributor.affiliatedLiu, Jia-Ren


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