dc.contributor.author | Shimomura, Yasuyo | |
dc.contributor.author | Ogawa, Atsuhiro | |
dc.contributor.author | Kawada, Mayumi | |
dc.contributor.author | Sugimoto, Ken | |
dc.contributor.author | Mizoguchi, Atsushi | |
dc.contributor.author | Shi, Hai-Ning | |
dc.contributor.author | Pillai, Shiv Subramaniam | |
dc.contributor.author | Bhan, Atul Kumar | |
dc.date.accessioned | 2011-04-23T04:15:07Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Shimomura, Yasuyo, Atsuhiro Ogawa, Mayumi Kawada, Ken Sugimoto, Emiko Mizoguchi, Hai-Ning Shi, Shiv Pillai, Atul K. Bhan, and Atsushi Mizoguchi. 2008. A unique B2 B cell subset in the intestine. The Journal of Experimental Medicine 205(6): 1343-1355. | en_US |
dc.identifier.issn | 0022-1007 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874782 | |
dc.description.abstract | Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM[super]+ B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We describe a previously unidentified and unique subset of immunoglobulin M[super]+ B cells that present with an AA4.1[super]−CD21[super]−CD23[super]− major histocompatibility complex class II[super]bright surface phenotype and are characterized by a low frequency of somatic hypermutation and the potential ability to produce interleukin-12p70. This B cell subset resides within the normal mucosa of the large intestine and expands in response to inflammation. Some of these intestinal B cells originate from the AA4.1[super]+ immature B2 cell pool in the steady state and are also recruited from the recirculating naive B cell pool in the context of intestinal inflammation. They develop in an antigen-independent and BAFF-dependent manner in the absence of T cell help. Expansion of these cells can be induced in the absence of the spleen and gut-associated lymphoid tissues. These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The Rockefeller University Press | en_US |
dc.relation.isversionof | doi:10.1084/jem.20071572 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413032/pdf/ | en_US |
dash.license | LAA | |
dc.title | A unique B2 B cell subset in the intestine | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | The Journal of Experimental Medicine | en_US |
dash.depositing.author | Pillai, Shiv Subramaniam | |
dc.date.available | 2011-04-23T04:15:07Z | |
dash.affiliation.other | HMS^Medicine-Massachusetts General Hospital | en_US |
dash.affiliation.other | HMS^Health Sciences and Technology | en_US |
dash.affiliation.other | HMS^Pathology | en_US |
dc.identifier.doi | 10.1084/jem.20071572 | * |
dash.contributor.affiliated | Mizoguchi, Atsushi | |
dash.contributor.affiliated | Bhan, Atul | |
dash.contributor.affiliated | Pillai, Shiv | |