Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

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Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

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dc.contributor.author Williams, Robert W
dc.contributor.author Rosen, Glenn David
dc.date.accessioned 2011-04-23T17:31:49Z
dc.date.issued 2001
dc.identifier.citation Rosen, Glenn D., and Robert W. Williams. 2001. Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number. BMC Neuroscience 2: 5. en_US
dc.identifier.issn 1471-2202 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874812
dc.description.abstract Background: The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia. Results: Brain weight, brain and striatal volume, neuron-packing density and number were estimated bilaterally using unbiased stereological procedures in five inbred strains (A/J, C57BL/6J, DBA/2J, BALB/cJ, and BXD5) and an F2 intercross between A/J and BXD5. Striatal volume ranged from 20 to 37 mm[super]3. Neuron-packing density ranged from approximately 50,000 to 100,000 neurons/mm[super]3, and the striatal neuron population ranged from 1.4 to 2.5 million. Inbred animals with larger brains had larger striata but lower neuron-packing density resulting in a narrow range of average neuron populations. In contrast, there was a strong positive correlation between volume and neuron number among intercross progeny. We mapped two quantitative trait loci (QTLs) with selective effects on striatal architecture. Bsc10a maps to the central region of Chr 10 (LRS of 17.5 near D10Mit186) and has intense effects on striatal volume and moderate effects on brain volume. Stnn19a maps to distal Chr 19 (LRS of 15 at D19Mit123) and is associated with differences of up to 400,000 neurons among animals. Conclusion: We have discovered remarkable numerical and volumetric variation in the mouse striatum, and we have been able to map two QTLs that modulate independent anatomic parameters. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1471-2202-2-5 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC31432/pdf/ en_US
dash.license LAA
dc.title Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Neuroscience en_US
dash.depositing.author Rosen, Glenn David
dc.date.available 2011-04-23T17:31:49Z
dash.affiliation.other HMS^Neurology- Beth Israel-Deaconess en_US

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