Divergent cortical generators of MEG and EEG during human sleep spindles suggested by distributed source modeling

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Divergent cortical generators of MEG and EEG during human sleep spindles suggested by distributed source modeling

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dc.contributor.author Dehghani, Nima
dc.contributor.author Hagler, Donald J.
dc.contributor.author Huang, Mingxiong
dc.contributor.author Dale, Anders M.
dc.contributor.author Halgren, Eric
dc.contributor.author Valdes-Sosa, Pedro Antonio
dc.contributor.author Cash, Sydney S.
dc.contributor.author Chen, Chih C.
dc.date.accessioned 2011-04-24T03:57:42Z
dc.date.issued 2010
dc.identifier.citation Dehghani, Nima, Sydney S. Cash, Chih C. Chen, Donald J. Hagler, Mingxiong Huang, Anders M. Dale, and Eric Halgren. 2010. Divergent cortical generators of MEG and EEG during human sleep spindles suggested by distributed source modeling. PLoS ONE 5(7): e11454. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874832
dc.description.abstract Background: Sleep spindles are ∼1-second bursts of 10–15 Hz activity, occurring during normal stage 2 sleep. In animals, sleep spindles can be synchronous across multiple cortical and thalamic locations, suggesting a distributed stable phase-locked generating system. The high synchrony of spindles across scalp EEG sites suggests that this may also be true in humans. However, prior MEG studies suggest multiple and varying generators. Methodology/Principal Findings: We recorded 306 channels of MEG simultaneously with 60 channels of EEG during naturally occurring spindles of stage 2 sleep in 7 healthy subjects. High-resolution structural MRI was obtained in each subject, to define the shells for a boundary element forward solution and to reconstruct the cortex providing the solution space for a noise-normalized minimum norm source estimation procedure. Integrated across the entire duration of all spindles, sources estimated from EEG and MEG are similar, diffuse and widespread, including all lobes from both hemispheres. However, the locations, phase and amplitude of sources simultaneously estimated from MEG versus EEG are highly distinct during the same spindles. Specifically, the sources estimated from EEG are highly synchronous across the cortex, whereas those from MEG rapidly shift in phase, hemisphere, and the location within the hemisphere. Conclusions/Significance: The heterogeneity of MEG sources implies that multiple generators are active during human sleep spindles. If the source modeling is correct, then EEG spindles are generated by a different, diffusely synchronous system. Animal studies have identified two thalamo-cortical systems, core and matrix, that produce focal or diffuse activation and thus could underlie MEG and EEG spindles, respectively. Alternatively, EEG spindles could reflect overlap at the sensors of the same sources as are seen from the MEG. Although our results generally match human intracranial recordings, additional improvements are possible and simultaneous intra- and extra-cranial measures are needed to test their accuracy. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0011454 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898804/pdf/ en_US
dash.license LAA
dc.subject neuroscience en_US
dc.subject cognitive neuroscience en_US
dc.subject neural homeostasis en_US
dc.title Divergent cortical generators of MEG and EEG during human sleep spindles suggested by distributed source modeling en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Cash, Sydney S.
dc.date.available 2011-04-24T03:57:42Z
dash.affiliation.other HMS^Neurology-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Psychiatry-Cambridge Hospital en_US

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