Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure
Steele, Lisa N.
Secor, W. Evan
MetadataShow full item record
CitationChenine, Agnès-Laurence, Ela Shai-Kobiler, Lisa N. Steele, Helena Ong, Peter Augostini, Ruijiang Song, Sandra J. Lee, Patrick Autissier, Ruth M. Ruprecht, and W. Evan Secor. 2008. Acute Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure. PLoS Neglected Tropical Diseases 2(7).
AbstractBackground: Individuals living in sub-Saharan Africa represent 10% of the world's population but almost 2/3 of all HIV-1/AIDS cases. The disproportionate HIV-1 infection rates in this region may be linked to helminthic parasite infections that affect many individuals in the developing world. However, the hypothesis that parasite infection increases an individual's susceptibility to HIV-1 has never been prospectively tested in a relevant in vivo model. Methodology/Principal Findings: We measured whether pre-existing infection of rhesus monkeys with a parasitic worm would facilitate systemic infection after mucosal AIDS virus exposure. Two groups of animals, one consisting of normal monkeys and the other harboring Schistosoma mansoni, were challenged intrarectally with decreasing doses of R5-tropic clade C simian-human immunodeficiency virus (SHIV-C). Systemic infection occurred in parasitized monkeys at viral doses that remained sub-infectious in normal hosts. In fact, the 50% animal infectious (AID50) SHIV-C dose was 17-fold lower in parasitized animals compared to controls (P<0.001). Coinfected animals also had significantly higher peak viral RNA loads than controls (P<0.001), as well as increased viral replication in CD4+ central memory cells (P = 0.03). Conclusions/Significance: Our data provide the first direct evidence that acute schistosomiasis significantly increases the risk of de novo AIDS virus acquisition, and the magnitude of the effect suggests that control of helminth infections may be a useful public health intervention to help decrease the spread of HIV-1.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4875086
- HMS Scholarly Articles 
Showing items related by title, author, creator and subject.
Characteristics of HCV Co-Infection among HIV Infected Individuals from an Area with High Risk of Blood-Borne Infections in Central China Zhang, Tiejun; Tully, Damien C.; Zhou, Sujuan; He, Na (Public Library of Science, 2014)Objective: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection has been proved to be a growing public health concern. The prevalence and genotypic pattern vary with geographic locations. Limited ...
Binagwaho, Agnes; Ratnayake, Niloo; Mukherjee, Joia Stapleton; Mugabo, Jules; Karita, Etienne; Pegurri, Elisabetta (African Field Epidemiology Network, 2010)This is an opinion piece based on data and experience from Rwanda. The authors believe this opinion piece may help improve current programs on prevention of HIV transmission from mother to child in Africa taking into account ...
Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers Martinot, Amanda Jezek; Meythaler, Mareike; Pozzi, Lu-Ann; Dalecki Boisvert, Karen; Knight, Heather Lynn; Walsh, Dennis; Westmoreland, Susan V.; Anderson, Daniel C.; Kaur, Amitinder; O’Neil, Shawn P. (Public Library of Science, 2013)Lymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts. To investigate factors contributing to this difference, we ...