Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset

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Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset

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Title: Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset
Author: Hardwick, Kevin G; Shah, Jagesh V.

Note: Order does not necessarily reflect citation order of authors.

Citation: Hardwick, Kevin G., and Jagesh V. Shah. 2010. Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset. F1000 Biology Reports 2: 55.
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Abstract: The spindle checkpoint delays anaphase onset in the presence of defective kinetochore-microtubule attachments. Such delays can last for just a few minutes or several hours, but very shortly after all chromosomes achieve bi-orientation, a remarkably synchronous anaphase ensues. We are beginning to understand the pathways involved in silencing spindle checkpoint signals and subsequent activation of the anaphase-promoting complex. Here, we review recent advances made in our understanding of the molecular mechanisms regulating this critical cell cycle transition.
Published Version: doi://10.3410/B2-55
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990540/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4875877
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