Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1

DSpace/Manakin Repository

Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1

Show simple item record Haas-Stapleton, Eric J. Lu, Yan Hong, Song Arita, Makoto Favoreto, Silvio Nigam, Santosh Agabian, Nina Serhan, Charles Nicholas 2011-04-26T01:58:22Z 2007
dc.identifier.citation Haas-Stapleton, Eric J., Yan Lu, Song Hong, Makoto Arita, Silvio Favoreto, Santosh Nigam, Charles N. Serhan, and Nina Agabian. 2007. Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. PLoS ONE 2(12): e1316. en_US
dc.identifier.issn 1932-6203 en_US
dc.description.abstract Candida albicans is an opportunistic fungal pathogen of humans that resides commensally on epithelial surfaces, but can cause inflammation when pathogenic. Resolvins are a class of anti-inflammatory lipids derived from omega-3 polyunsaturated fatty acids (PUFA) that attenuate neutrophil migration during the resolution phase of inflammation. In this report we demonstrate that C. albicans biosynthesizes resolvins that are chemically identical to those produced by human cells. In contrast to the trans-cellular biosynthesis of human Resolvin E1 (RvE1), RvE1 biosynthesis in C. albicans occurs in the absence of other cellular partners. C. albicans biosynthesis of RvE1 is sensitive to lipoxygenase and cytochrome P450 monoxygenase inhibitors. We show that 10nM RvE1 reduces neutrophil chemotaxis in response to IL-8; 1nM RvE1 enhanced phagocytosis of Candida by human neutrophils, as well as intracellular ROS generation and killing, while having no direct affect on neutrophil motility. In a mouse model of systemic candidiasis, RvE1 stimulated clearance of the fungus from circulating blood. These results reveal an inter-species chemical signaling system that modulates host immune functions and may play a role in balancing host carriage of commensal and pathogenic C. albicans. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0001316 en_US
dc.relation.hasversion en_US
dash.license LAA
dc.subject immunology en_US
dc.subject immunomodulation en_US
dc.subject innate immunity en_US
dc.subject immunity to infections en_US
dc.subject microbiology en_US
dc.subject medical microbiology en_US
dc.subject infectious diseases en_US
dc.subject fungal infections en_US
dc.subject HIV infection and AIDS en_US
dc.subject nosocomial and healthcare-associated infections en_US
dc.title Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1 en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US Serhan, Charles Nicholas 2011-04-26T01:58:22Z
dash.affiliation.other HMS^Anaesthesia-Brigham and Women's Hospital en_US

Files in this item

Files Size Format View
2134765.pdf 302.9Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record


Search DASH

Advanced Search