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dc.contributor.authorLiu, Hongye
dc.contributor.authorKohane, Isaac Samuel
dc.date.accessioned2011-04-28T04:09:24Z
dc.date.issued2009
dc.identifier.citationLiu, Hongye and Issac S. Kohane. 2009. Tissue and Process Specific microRNA-mRNA Co-Expression in Mammalian Development and Malignancy. PLoS ONE 4(5): e5436.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4878919
dc.description.abstractAn association between enrichment and depletion of microRNA (miRNA) binding sites, 3′ UTR length, and mRNA expression has been demonstrated in various developing tissues and tissues from different mature organs; but functional, context-dependent miRNA regulations have yet to be elucidated. Towards that goal, we examined miRNA–mRNA interactions by measuring miRNA and mRNA in the same tissue during development and also in malignant conditions. We identified significant miRNA-mediated biological process categories in developing mouse cerebellum and lung using non-targeted mRNA expression as the negative control. Although miRNAs in general suppress target mRNA messages, many predicted miRNA targets demonstrate a significantly higher level of co-expression than non-target genes in developing cerebellum. This phenomenon is tissue specific since it is not observed in developing lungs. Comparison of mouse cerebellar development and medulloblastoma demonstrates a shared miRNA–mRNA co-expression program for brain-specific neurologic processes such as synaptic transmission and exocytosis, in which miRNA target expression increases with the accumulation of multiple miRNAs in developing cerebellum and decreases with the loss of these miRNAs in brain tumors. These findings demonstrate the context-dependence of miRNA–mRNA co-expression.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0005436en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673043/pdf/en_US
dash.licenseLAA
dc.subjectdevelopmental biologyen_US
dc.subjectneurodevelopmenten_US
dc.subjectgenetics and genomicsen_US
dc.subjectbioinformaticsen_US
dc.subjectcancer geneticsen_US
dc.subjectfunctional genomicsen_US
dc.subjectgene expressionen_US
dc.subjectneuroscienceen_US
dc.titleTissue and Process Specific microRNA–mRNA Co-Expression in Mammalian Development and Malignancyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorKohane, Isaac Samuel
dc.date.available2011-04-28T04:09:24Z
dash.affiliation.otherHMS^Countway Library of Medicineen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0005436*
dash.contributor.affiliatedLiu, Hongye
dash.contributor.affiliatedKohane, Isaac


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