Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research

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Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research

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dc.contributor.author Wright, Rosalind Jo
dc.date.accessioned 2011-04-28T05:37:55Z
dc.date.issued 2008
dc.identifier.citation Wright, Rosalind J. 2008. Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research. Allergy, Asthma, and Clinical Immunology 4(1): 29-36. en_US
dc.identifier.issn 1710-1484 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878932
dc.description.abstract Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamicpituitary-adrenocortical (HPA) axis] provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual's susceptibility to other environmental factors that may also contribute to asthma risk. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1710-1492-4-1-29 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869338/pdf/ en_US
dash.license LAA
dc.subject asthma en_US
dc.subject childhood en_US
dc.subject interactions en_US
dc.subject prenatal en_US
dc.subject stress en_US
dc.title Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Allergy, Asthma, and Clinical Immunology en_US
dash.depositing.author Wright, Rosalind Jo
dc.date.available 2011-04-28T05:37:55Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US

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