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dc.contributor.authorVerdier, Valerie
dc.contributor.authorSettleman, Jeffrey Evan
dc.date.accessioned2011-04-28T23:36:50Z
dc.date.issued2006
dc.identifier.citationVerdier, Valerie, Guang-Chao-Chen, and Jeffrey Settleman. 2006. Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development. BMC Developmental Biology 6: 38.en_US
dc.identifier.issn1471-213Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4879185
dc.description.abstractBackground: The Rho-kinases (ROCKs) are major effector targets of the activated Rho GTPase that have been implicated in many of the Rho-mediated effects on cell shape and movement via their ability to affect acto-myosin contractility. The role of ROCKs in cell shape change and motility suggests a potentially important role for Rho-ROCK signaling in tissue morphogenesis during development. Indeed, in Drosophila, a single ROCK ortholog, DRok, has been identified and has been found to be required for establishing planar cell polarity. Results: We have examined a potential role for DRok in additional aspects of tissue morphogenesis using an activated form of the protein in transgenic flies. Our findings demonstrate that DRok activity can influence multiple morphogenetic processes, including eye and wing development. Furthermore, genetic studies reveal that Drok interacts with multiple downstream effectors of the Rho GTPase signaling pathway, including non-muscle myosin heavy chain, adducin, and Diaphanous in those developmental processes. Finally, in overexpression studies, we determined that Drok and Drosophila Lim-kinase interact in the developing nervous system. Conclusion: These findings indicate widespread diverse roles for DRok in tissue morphogenesis during Drosophila development, in which multiple DRok substrates appear to be required.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-213X-6-38en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1552057/pdf/en_US
dash.licenseLAA
dc.titleRho-kinase Regulates Tissue Morphogenesis Via Non-muscle Myosin and LIM-Kinase During Drosophila Developmenten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Developmental Biologyen_US
dash.depositing.authorSettleman, Jeffrey Evan
dc.date.available2011-04-28T23:36:50Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dc.identifier.doi10.1186/1471-213X-6-38*
dash.contributor.affiliatedSettleman, Jeffrey Evan


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