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dc.contributor.authorFukazawa, Atsuko
dc.contributor.authorAlonso, Carmen
dc.contributor.authorKurachi, Kiyotaka
dc.contributor.authorGupta, Sonal
dc.contributor.authorPhilpott, Dana J.
dc.contributor.authorLesser, Cammie
dc.contributor.authorMcCormick, Beth A.
dc.contributor.authorReinecker, Hans-Christian
dc.date.accessioned2011-04-29T01:45:18Z
dc.date.issued2008
dc.identifier.citationFukazawa, Atsuko, Carmen Alonso, Kiyotaka Kurachi, Sonal Gupta, Cammie F. Lesser, Beth Ann McCormick, and Hans-Christian Reinecker. 2008. GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors. PLoS Pathogens 4(11): e1000228.en_US
dc.identifier.issn1553-7366en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4879197
dc.description.abstractShigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange factor H1 (GEF-H1) mediates RhoA activation required for cell invasion by the enteroinvasive pathogen Shigella flexneri. Surprisingly, GEF-H1 is requisite for NF-κB activation in response to Shigella infection. GEF-H1 interacts with NOD1 and is required for RIP2 dependent NF-κB activation by H-Ala-D-γGlu-DAP (γTriDAP). GEF-H1 is essential for NF-κB activation by the Shigella effectors IpgB2 and OspB, which were found to signal in a NOD1 and RhoA Kinase (ROCK) dependent manner. Our results demonstrate that GEF-H1 is a critical component of cellular defenses forming an intracellular sensing system with NOD1 for the detection of microbial effectors during cell invasion by pathogens.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.ppat.1000228en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583055/pdf/en_US
dash.licenseLAA
dc.subjectcell biologyen_US
dc.subjectcell signalingen_US
dc.subjectcytoskeletonen_US
dc.subjectgastroenterology and hepatologyen_US
dc.subjectgastrointestinal infectionsen_US
dc.subjectimmunologyen_US
dc.subjectinnate immunityen_US
dc.subjectmicrobiologyen_US
dc.titleGEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectorsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Pathogensen_US
dash.depositing.authorLesser, Cammie
dc.date.available2011-04-29T01:45:18Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Pediatrics-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dc.identifier.doi10.1371/journal.ppat.1000228*
dash.authorsorderedfalse
dash.contributor.affiliatedMcCormick, Beth A.
dash.contributor.affiliatedLesser, Cammie
dash.contributor.affiliatedReinecker, Hans-Christian


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