Emotional enhancement of memory: how norepinephrine enables synaptic plasticity

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Emotional enhancement of memory: how norepinephrine enables synaptic plasticity

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Title: Emotional enhancement of memory: how norepinephrine enables synaptic plasticity
Author: Tully, Keith Leo; Bolshakov, Vadim

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Citation: Tully, Keith, and Vadim Y. Bolshakov. 2010. Emotional enhancement of memory: how norepinephrine enables synaptic plasticity. Molecular Brain 3: 15.
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Abstract: Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms. Emotional arousal leads to activation of the locus coeruleus with the subsequent release of norepineprine in the brain, resulting in the enhancement of memory. Norepinephrine activates both pre- and post-synaptic adrenergic receptors at central synapses with different functional outcomes, depending on the expression pattern of these receptors in specific neural circuitries underlying distinct behavioral processes. We review the evidence for noradrenergic modulation of synaptic plasticity with consideration of how this may contribute to the mechanisms of learning and memory.
Published Version: doi:10.1186/1756-6606-3-15
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877027/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879198
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