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dc.contributor.authorO’Neill, Marie S.
dc.contributor.authorPark, Sung Kyun
dc.contributor.authorVokonas, Pantel S
dc.contributor.authorSparrow, David
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2011-05-01T04:16:53Z
dc.date.issued2004
dc.identifier.citationPark, Sung Kyun, Marie S. O'Neill, Pantel S. Vokonas, David Sparrow, and Joel Schwartz. 2005. Effects of air pollution on heart rate variability: the VA Normative Aging Study. Environmental Health Perspectives 113(3): 304-309.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4879856
dc.description.abstractReduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameter (PM\(_{2.5}\))]. We examined the relationship between HRV [standard deviation of normal-to-normal intervals (SDNN), power in high frequency (HF) and low frequency (LF), and LF:HF ratio] and ambient air pollutants in 497 men from the Normative Aging Study in greater Boston, Massachusetts, seen between November 2000 and October 2003. We examined 4-hr, 24-hr, and 48-hr moving averages of air pollution (PM\(_{2.5}\), particle number concentration, black carbon, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide). Controlling for potential confounders, HF decreased 20.8% [95% confidence interval (CI), 4.6–34.2%] and LF:HF ratio increased 18.6% (95% CI, 4.1–35.2%) per SD (8 μg/m\(^3\)) increase in 48-hr PM\(_{2.5}\). LF was reduced by 11.5% (95% CI, 0.4–21.3%) per SD (13 ppb) increment in 4-hr O\(_3\). The associations between HRV and PM\(_{2.5}\) and O\(_3\) were stronger in people with ischemic heart disease (IHD) and hypertension. The associations observed between SDNN and LF and PM\(_{2.5}\) were stronger in people with diabetes. People using calcium-channel blockers and beta-blockers had lower associations between O\(_3\) and PM\(_{2.5}\) with LF. No effect modification by other cardiac medications was found. Exposures to PM\(_{2.5}\) and O\(_3\) are associated with decreased HRV, and history of IHD, hypertension, and diabetes may confer susceptibility to autonomic dysfunction by air pollution.en_US
dc.language.isoen_USen_US
dc.publisherNational Institue of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.7447en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253756/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectdiabetesen_US
dc.subjectheart rate variabilityen_US
dc.subjecthypertensionen_US
dc.subjectischemic heart diseaseen_US
dc.subjectozoneen_US
dc.subjectPM\(_{2.5}\)en_US
dc.titleEffects of air pollution on heart rate variability: the VA Normative Aging Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorSchwartz, Joel David
dc.date.available2011-05-01T04:16:53Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1289/ehp.7447*
dash.authorsorderedfalse
dash.contributor.affiliatedVokonas, Pantel
dash.contributor.affiliatedSparrow, David
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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