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dc.contributor.authorHauser, Russ B.
dc.contributor.authorChen, Zuying
dc.contributor.authorPothier, Lucille J.
dc.contributor.authorRyan, Louise Marie
dc.contributor.authorAltshul, Larisa M.
dc.date.accessioned2011-05-01T04:21:53Z
dc.date.issued2003
dc.identifier.citationHauser, Russ, Zuying Chen, Lucille Pothier, Louise Ryan, and Larisa Altshul. 2003. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and \(p,p'\)-DDE. Environmental Health Perspectives 111(12): 1505-1511.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4879857
dc.description.abstractScientific and public concern exists about potential reproductive health effects of persistent chlorinated organic chemicals, such as polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE, the most stable daughter compound of DDT). To explore the hypothesis that environmental exposures to PCBs and DDE are associated with altered semen parameters, we conducted a cross-sectional study of 212 male partners of subfertile couples who presented to the Massachusetts General Hospital Andrology Laboratory. Semen parameters were analyzed as both a continuous measure and dichotomized based on World Health Organization reference values for sperm concentration (< 20 million/mL), motility (< 50% motile), and Kruger strict criteria for morphology (< 4% normal). The comparison group for the dichotomized analysis was men with all three semen parameters above the reference values. In serum, 57 PCB congeners and \(p,p'\)-DDE were measured by congener-specific analysis using gas chromatography with electron capture detection. There were dose-response relationships among PCB-138 and sperm motility (odds ratio per tertile, adjusted for age, abstinence, and smoking, and \(p\)-value for trend were, respectively, 1.00, 1.68, 2.35, and \(p\)-value = 0.03) and morphology (1.00, 1.36, 2.53, \(p\)-value = 0.04). There was limited evidence of an inverse relationship between sum of PCBs, as well as those PCBs classified as cytochrome P450 enzyme inducers, with sperm motility and sperm morphology, as well as limited evidence of an inverse association between \(p,p'\)-DDE and sperm motility. The lack of a consistent relationship among semen parameters and other individual PCB congeners and groupings of congeners may indicate a difference in spermatotoxicity between congeners.en_US
dc.language.isoen_USen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241654/pdf/en_US
dash.licenseLAA
dc.subjectDDTen_US
dc.subjectenvironmental healthen_US
dc.subjectpolychlorinated biphenylsen_US
dc.subjectreproductive healthen_US
dc.subjectsemenen_US
dc.subjectspermen_US
dc.titleThe relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and \(p,p'\)-DDEen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorHauser, Russ B.
dc.date.available2011-05-01T04:21:53Z
dash.affiliation.otherHMS^Obstetrics Gynecology and Repro. Bio. - MGHen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.contributor.affiliatedRyan, Louise
dash.contributor.affiliatedPothier, Lucille
dash.contributor.affiliatedHauser, Russ
dash.contributor.affiliatedAltshul, Larisa


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