PM\(_{2.5}\) metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers

DSpace/Manakin Repository

PM\(_{2.5}\) metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers

Show simple item record

dc.contributor.author Cavallari, Jennifer Margaret
dc.contributor.author Eisen, Ellen A.
dc.contributor.author Fang, Shona C.
dc.contributor.author Schwartz, Joel David
dc.contributor.author Hauser, Russ B.
dc.contributor.author Herrick, Robert F.
dc.contributor.author Christiani, David C.
dc.date.accessioned 2011-05-01T04:27:08Z
dc.date.issued 2008
dc.identifier.citation Cavallari, Jennifer M., Ellen A. Eisen, Shona C. Fang, Joel Schwartz, Russ Hauser, Robert F. Herrick, and David C. Christiani. 2008. PM\(_{2.5}\) metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers. Environmental Health 7: 36. en_US
dc.identifier.issn 1476-069X en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879858
dc.description.abstract Background: To better understand the mechanism(s) of particulate matter (PM) associated cardiovascular effects, research priorities include identifying the responsible PM characteristics. Evidence suggests that metals play a role in the cardiotoxicity of fine PM (PM\(_{2.5}\)) and in exposure-related decreases in heart rate variability (HRV). We examined the association between daytime exposure to the metal content of PM\(_{2.5}\) and night HRV in a panel study of boilermaker construction workers exposed to metal-rich welding fumes. Methods: Twenty-six male workers were monitored by ambulatory electrocardiogram (ECG) on a workday while exposed to welding fume and a non-workday (baseline). From the ECG, rMSSD (square root of the mean squared differences of successive intervals) was summarized over the night (0:00–7:00). Workday, gravimetric PM\(_{2.5}\) samples were analyzed by x-ray fluorescence to determine metal content. We used linear mixed effects models to assess the associations between night rMSSD and PM\(_{2.5}\) metal exposures both with and without adjustment for total PM\(_{2.5}\). Matched ECG measurements from the non-workday were used to control for individual cardiac risk factors and models were also adjusted for smoking status. To address collinearity between PM\(_{2.5}\) and metal content, we used a two-step approach that treated the residuals from linear regression models of each metal on PM\(_{2.5}\) as surrogates for the differential effects of metal exposures in models for night rMSSD. Results: The median PM\(_{2.5}\) exposure was 650 μg/m\(^3\); median metal exposures for iron, manganese, aluminum, copper, zinc, chromium, lead, and nickel ranged from 226 μg/m\(^3\) to non-detectable. We found inverse linear associations in exposure-response models with increased metal exposures associated with decreased night rMSSD. A statistically significant association for manganese was observed, with a decline of 0.130 msec (95% CI: -0.162, -0.098) in night rMSSD for every 1 μg/m\(^3\) increase in manganese. However, even after adjusting for individual metals, increases in total PM\(_{2.5}\) exposures were associated with declines in night rMSSD. Conclusion: These results support the cardiotoxicity of PM\(_{2.5}\) metal exposures, specifically manganese. However the metal component alone did not account for the observed declines in night HRV. Therefore, results suggest the importance of other PM elemental components. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1476-069X-7-36 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481261/pdf/ en_US
dash.license LAA
dc.title PM\(_{2.5}\) metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health en_US
dash.depositing.author Cavallari, Jennifer Margaret
dc.date.available 2011-05-01T04:27:08Z
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Obstetrics Gynecology and Repro. Bio. - MGH en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Massachusetts General Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US

Files in this item

Files Size Format View
2481261.pdf 258.2Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters