HSP60 as a Target of Anti-Ergotypic Regulatory T Cells

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HSP60 as a Target of Anti-Ergotypic Regulatory T Cells

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Title: HSP60 as a Target of Anti-Ergotypic Regulatory T Cells
Author: Mimran, Avishai; Carmi, Pnina; Mor, Felix; Cohen, Irun R.; Quintana, Francisco Javier

Note: Order does not necessarily reflect citation order of authors.

Citation: Quintana, Francisco J., Avishai Mimran, Pnina Carmi, Felix Mor, and Irun R. Cohen. 2008. HSP60 as a target of anti-ergotypic regulatory T cells. PLoS ONE 3(12): e4026.
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Abstract: The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60 is up-regulated and presented by activated T cells (HSP60 is an ergotope) to regulatory (anti-ergotypic) T cells. Presentation of HSP60 by activated T cells was found to be MHC-restricted and dependent on accessory molecules - CD28, CD80 and CD86. Anti-ergotypic T cells responded to T-cell HSP60 by proliferation and secreted IFNγ and TGFβ1. In vitro, the anti-ergotypic T cells inhibited IFNγ production by their activated T-cell targets. In vivo, adoptive transfer of an anti-ergotypic HSP60-specific T-cell line led to decreased secretion of IFNγ by arthritogenic T cells and ameliorated adjuvant arthritis (AA). Thus, the presentation of HSP60 by activated T cells turns them into targets for anti-ergotypic regulatory T cells specific for HSP60. However, the direct interaction between the anti-ergotypic T regulators (anti-HSP60) and the activated T cells also down-regulated the regulators. Thus, by functioning as an ergotope, HSP60 can control both the effector T cells and the regulatory HSP60-specific T cells that control them.
Published Version: doi:10.1371/journal.pone.0004026
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602852/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4882757
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