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dc.contributor.authorPierson, Christopher R.
dc.contributor.authorFolkerth, Rebecca Dunn
dc.contributor.authorBilliards, Saraid S.
dc.contributor.authorTrachtenberg, Felicia L.
dc.contributor.authorDrinkwater, Mark E.
dc.contributor.authorVolpe, Joseph John
dc.contributor.authorKinney, Hannah Chase
dc.date.accessioned2011-05-06T17:37:15Z
dc.date.issued2007
dc.identifier.citationPierson, Christopher R., Rebecca D. Folkerth, Saraid S. Billiards, Felicia L. Trachtenberg, Mark E. Drinkwater, Joseph J. Volpe, and Hannah C. Kinney. 2007. Gray matter injury associated with periventricular leukomalacia in the premature infant. Acta Neuropathologica 114(6): 619-631.en_US
dc.identifier.issn0001-6322en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4882822
dc.description.abstractNeuroimaging studies indicate reduced volumes of certain gray matter regions in survivors of prematurity with periventricular leukomalacia (PVL). We hypothesized that subacute and/or chronic gray matter lesions are increased in incidence and severity in PVL cases compared to non-PVL cases at autopsy. Forty-one cases of premature infants were divided based on cerebral white matter histology: PVL (n = 17) with cerebral white matter gliosis and focal periventricular necrosis; diffuse white matter gliosis (DWMG) (n = 17) without necrosis; and “Negative” group (n = 7) with no abnormalities. Neuronal loss was found almost exclusively in PVL, with significantly increased incidence and severity in the thalamus (38%), globus pallidus (33%), and cerebellar dentate nucleus (29%) compared to DWMG cases. The incidence of gliosis was significantly increased in PVL compared to DWMG cases in the deep gray nuclei (thalamus/basal ganglia; 50–60% of PVL cases), and basis pontis (100% of PVL cases). Thalamic and basal ganglionic lesions occur almost exclusively in infants with PVL. Gray matter lesions occur in a third or more of PVL cases suggesting that white matter injury generally does not occur in isolation, and that the term “perinatal panencephalopathy” may better describe the scope of the neuropathology.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofdoi:10.1007/s00401-007-0295-5en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080348/pdf/en_US
dash.licenseLAA
dc.subjectbasal gangliaen_US
dc.subjectbrainstemen_US
dc.subjectperinatal panencephalopathyen_US
dc.subjectneurodevelopmental disabilityen_US
dc.subjectperinatal hypoxia–ischemiaen_US
dc.subjectwhite matter gliosisen_US
dc.subjectthalamusen_US
dc.titleGray Matter Injury Associated with Periventricular Leukomalacia in the Premature Infanten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalActa Neuropathologicaen_US
dash.depositing.authorFolkerth, Rebecca Dunn
dc.date.available2011-05-06T17:37:15Z
dash.affiliation.otherHMS^Pathologyen_US
dash.affiliation.otherHMS^Neurology-Children's Hospitalen_US
dc.identifier.doi10.1007/s00401-007-0295-5*
dash.contributor.affiliatedKinney, Hannah
dash.contributor.affiliatedVolpe, Joseph
dash.contributor.affiliatedFolkerth, Rebecca D.


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