Show simple item record

dc.contributor.authorQuintana, Francisco Javier
dc.contributor.authorIglesias, Antonio H.
dc.contributor.authorFarez, Mauricio F.
dc.contributor.authorCaccamo, Mario
dc.contributor.authorBurns, Evan J.
dc.contributor.authorKassam, Nasim
dc.contributor.authorOukka, Mohamed
dc.contributor.authorWeiner, Howard Lee
dc.date.accessioned2011-05-06T17:45:59Z
dc.date.issued2010
dc.identifier.citationQuintana, Francisco J., Antonio H. Iglesias, Mauricio F. Farez, Mario Caccamo, Evan J. Burns, Nasim Kassam, Mohamed Oukka, and Howard L. Weiner. 2010. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS ONE 5(3).en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4882825
dc.description.abstractBackground: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens is enforced by Foxp3+ regulatory T cells. Recombinatorial mechanisms also operate in teleosts, but active immunoregulation is thought to be a late incorporation to the vertebrate lineage. Methods/Principal Findings: Here we report the characterization of adaptive autoimmunity and Foxp3-based immunoregulation in the zebrafish. We found that zebrafish immunization with an homogenate of zebrafish central nervous system (zCNS) triggered CNS inflammation and specific antibodies. We cloned the zebrafish ortholog for mammalian Foxp3 (zFoxp3) which induced a regulatory phenotype on mouse T cells and controlled IL-17 production in zebrafish embryos. Conclusions/Significance: Our findings demonstrate the acquisition of active mechanisms of self-tolerance early in vertebrate evolution, suggesting that active regulatory mechanisms accompany the development of the molecular potential for adaptive autoimmunity. Moreover, they identify the zebrafish as a tool to study the molecular pathways controlling adaptive immunity.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi://10.1371/journal.pone.0009478en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832694/pdf/en_US
dash.licenseLAA
dc.subjectimmunologyen_US
dc.subjectautoimmunityen_US
dc.subjectimmune responseen_US
dc.subjectimmunomodulationen_US
dc.titleAdaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafishen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorWeiner, Howard Lee
dc.date.available2011-05-06T17:45:59Z
dash.affiliation.otherHMS^Neurology-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Neurology-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0009478*
dash.contributor.affiliatedOukka, Mohamed
dash.contributor.affiliatedQuintana, Francisco
dash.contributor.affiliatedWeiner, Howard
dc.identifier.orcid0000-0003-0203-9681


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record