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dc.contributor.authorDonnell, Deborah
dc.contributor.authorMimiaga, Matthew James
dc.contributor.authorMayer, Kenneth Hugh
dc.contributor.authorChesney, Margaret
dc.contributor.authorKoblin, Beryl
dc.contributor.authorCoates, Thomas
dc.date.accessioned2011-05-07T23:24:21Z
dc.date.issued2010
dc.identifier.citationDonnell, Deborah, Matthew J. Mimiaga, Kenneth Mayer, Margaret Chesney, Beryl Koblin, and Thomas Coates. 2010. Use of non-occupational post-exposure prophylaxis does not lead to an Increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial. AIDS and Behavior 14(5): 1182-1189.en_US
dc.identifier.issn1090-7165en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4882977
dc.description.abstractNon-occupational post-exposure prophylaxis (nPEP) use is an HIV prevention strategy that has been recommended by the CDC to prevent HIV infection after a high risk sexual exposure since 1997. In a behavioral intervention trial of 4,295 MSM we assessed perceptions and use of nPEP over 4 years in six cities across the United States. Overall, 1.9% of MSM reported use of nPEP prior to enrollment, and 6.3% at least once during the trial. Awareness of nPEP was reported by 47.5%, with higher awareness in two sites with funded nPEP programs. Three seroconversions occurred in the 384 visits where nPEP courses were reported, with no effect of nPEP on risk of HIV acquisition in this cohort (hazard ratio = 0.91, 95% confidence interval [0.29, 2.86]). NPEP users were a riskier group: increased odds of nPEP use were observed in association with multiple partners and unprotected receptive and insertive anal sex with HIV infected partners and partners with unknown HIV status. NPEP use was also associated with use of illicit drugs (injection drugs, crack cocaine, hallucinogens, and amphetamines). Importantly, willingness to use nPEP after high risk sex was associated with lower odds of high risk sex. After an episode of nPEP use, nPEP users remained more likely to report high risk sex than those in this cohort who had not previously used nPEP. However, within the subset of people who had previously reported high risk sex, previous nPEP use was not associated with higher odds of high risk sex, thus allaying fears that availability of nPEP would lead to an increase in high risk sex.en_US
dc.language.isoen_USen_US
dc.publisherSpringer USen_US
dc.relation.isversionofdoi://10.1007/s10461-010-9712-1en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944957/pdf/en_US
dash.licenseLAA
dc.subjectMSMen_US
dc.subjectHIVen_US
dc.subjectPEPen_US
dc.subjectBehavioral disinhibitionen_US
dc.titleUse of Non-Occupational Post-Exposure Prophylaxis does not Lead to an Increase in High Risk Sex Behaviors in Men Who have Sex with Men Participating in the EXPLORE Trialen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalAIDS and Behavioren_US
dash.depositing.authorMimiaga, Matthew James
dc.date.available2011-05-07T23:24:21Z
dash.affiliation.otherHMS^Psychiatry-Massachusetts General Hospitalen_US
dc.identifier.doi10.1007/s10461-010-9712-1*
dash.contributor.affiliatedMayer, Kenneth
dash.contributor.affiliatedMimiaga, Matthew J.


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