p38 MAPK, Microglial Signaling, and Neuropathic Pain

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p38 MAPK, Microglial Signaling, and Neuropathic Pain

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Title: p38 MAPK, Microglial Signaling, and Neuropathic Pain
Author: Ji, Ru-Rong; Suter, Marc

Note: Order does not necessarily reflect citation order of authors.

Citation: Ji, Ru-Rong, and Marc R Suter. 2007. p38 MAPK, microglial signaling, and neuropathic pain. Molecular Pain 3: 33.
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Abstract: Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management.
Published Version: doi://10.1186/1744-8069-3-33
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186318/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4882980
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