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dc.contributor.authorPrice, Alkes
dc.contributor.authorPatterson, Nick
dc.contributor.authorHancks, Dustin C.
dc.contributor.authorMyers, Simon
dc.contributor.authorReich, David Emil
dc.contributor.authorCheung, Vivian G.
dc.contributor.authorSpielman, Richard S.
dc.date.accessioned2011-05-10T00:09:01Z
dc.date.issued2008
dc.identifier.citationPrice, Alkes L., Nick Patterson, Dustin C. Hancks, Simon Myers, David Reich, Vivian G. Cheung, and Richard S. Spielman. 2008. Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans. PLoS Genetics 4(12): e1000294.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4885947
dc.description.abstractVariation in gene expression is a fundamental aspect of human phenotypic variation. Several recent studies have analyzed gene expression levels in populations of different continental ancestry and reported population differences at a large number of genes. However, these differences could largely be due to non-genetic (e.g., environmental) effects. Here, we analyze gene expression levels in African American cell lines, which differ from previously analyzed cell lines in that individuals from this population inherit variable proportions of two continental ancestries. We first relate gene expression levels in individual African Americans to their genome-wide proportion of European ancestry. The results provide strong evidence of a genetic contribution to expression differences between European and African populations, validating previous findings. Second, we infer local ancestry (0, 1, or 2 European chromosomes) at each location in the genome and investigate the effects of ancestry proximal to the expressed gene (cis) versus ancestry elsewhere in the genome (trans). Both effects are highly significant, and we estimate that 12±3% of all heritable variation in human gene expression is due to cis variants.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1000294en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586034/pdf/en_US
dash.licenseLAA
dc.subjectgenetics and genomicsen_US
dc.subjectgene expressionen_US
dc.subjectpopulation geneticsen_US
dc.titleEffects of cis and trans Genetic Ancestry on Gene Expression in African Americansen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorPrice, Alkes
dc.date.available2011-05-10T00:09:01Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Geneticsen_US
dc.identifier.doi10.1371/journal.pgen.1000294*
dash.contributor.affiliatedPrice, Alkes
dash.contributor.affiliatedReich, David


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