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dc.contributor.authorZanobetti, Antonella
dc.contributor.authorGold, Diane R.
dc.contributor.authorStone, Peter Howard
dc.contributor.authorSuh MacIntosh, Helen H.
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorSpeizer, Frank Erwin
dc.date.accessioned2011-05-10T01:49:03Z
dc.date.issued2009
dc.identifier.citationZanobetti, Antonella, Diane R. Gold, Peter H. Stone, Helen H. Suh, Joel Schwartz, Brent A. Coull, and Frank E. Speizer. 2010. Reduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Disease. Environmental Health Perspectives 118(3): 324-330.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4885972
dc.description.abstractIntroduction: Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction. Methods: In a repeated-measures study of 46 patients 43–75 years of age, we investigated associations of central-site ambient particulate pollution, including black carbon (BC) (a marker for regional and local traffic), and report of traffic exposure with changes in half-hourly averaged heart rate variability (HRV), a marker of autonomic function measured by 24-hr Holter electrocardiogram monitoring. Each patient was observed up to four times within 1 year after a percutaneous intervention for myocardial infarction, acute coronary syndrome without infarction, or stable coronary artery disease (4,955 half-hour observations). For each half-hour period, diary data defined whether the patient was home or not home, or in traffic. Results: A decrease in high frequency (HF; an HRV marker of vagal tone) of −16.4% [95% confidence interval (CI), −20.7 to −11.8%] was associated with an interquartile range of 0.3-μg/m3 increase in prior 5-day averaged ambient BC. Decreases in HF were independently associated both with the previous 2-hr averaged BC (−10.4%; 95% CI, −15.4 to −5.2%) and with being in traffic in the previous 2 hr (−38.5%; 95% CI, −57.4 to −11.1%). We also observed independent responses for particulate air matter with aerodynamic diameter ≤ 2.5 μm and for gases (ozone or nitrogen dioxide). Conclusion: After hospitalization for coronary artery disease, both particulate pollution and being in traffic, a marker of stress and pollution, were associated with decreased HRV.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0901003en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854758/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectcardiac eventen_US
dc.subjectheart rate variabilityen_US
dc.subjectmyocardial infarctionen_US
dc.subjecttrafficen_US
dc.titleReduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Diseaseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorSpeizer, Frank Erwin
dc.date.available2011-05-10T01:49:03Z
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Program-EEen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1289/ehp.0901003*
dash.authorsorderedfalse
dash.contributor.affiliatedStone, Peter
dash.contributor.affiliatedSuh MacIntosh, Helen H.
dash.contributor.affiliatedSpeizer, Frank
dash.contributor.affiliatedGold, Diane
dash.contributor.affiliatedZanobetti, Antonella
dash.contributor.affiliatedCoull, Brent
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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