Show simple item record

dc.contributor.authorHoxha, Mirjam
dc.contributor.authorDioni, Laura
dc.contributor.authorBonzini, Matteo
dc.contributor.authorPesatori, Angela Cecilia
dc.contributor.authorFustinoni, Silvia
dc.contributor.authorCavallo, Domenico
dc.contributor.authorCarugno, Michele
dc.contributor.authorAlbetti, Benedetta
dc.contributor.authorMarinelli, Barbara
dc.contributor.authorBertazzi, Pier Alberto
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorBaccarelli, Andrea
dc.date.accessioned2011-05-11T01:40:36Z
dc.date.issued2009
dc.identifier.citationHoxha, Mirjam, Laura Dioni, Matteo Bonzini, Angela Cecilia Pesatori, Silvia Fustinoni, Domenico Cavallo, Michele Carugno, et al. 2009. Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers. Environmental Health 8: 41.en_US
dc.identifier.issn1476-069Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4887103
dc.description.abstractBackground: Telomere shortening in blood leukocytes has been associated with increased morbidity and death from cardiovascular disease and cancer, but determinants of shortened telomeres, a molecular feature of biological aging, are still largely unidentified. Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated. Methods: We measured leukocyte telomere length (LTL) by real-time PCR in blood DNA from 77 traffic officers exposed to high levels of traffic pollutants and 57 office workers (referents). Airborne benzene and toluene, as tracers for traffic exposure, were measured using personal passive samplers and gas-chromatography/flame-ionization detector analysis. We used covariate-adjusted multivariable models to test the effects of the exposure on LTL and obtain adjusted LTL means and 95% Confidence Intervals (CIs). Results: Adjusted mean LTL was 1.10 (95%CI 1.04-1.16) in traffic officers and 1.27 in referents (95%CI 1.20-1.35) [p < 0.001]. LTL decreased in association with age in both traffic officers (p = 0.01) and referents (p = 0.001), but traffic officers had shorter LTL within each age category. Among traffic officers, adjusted mean relative LTL was shorter in individuals working in high (n = 45, LTL = 1.02, 95%CI 0.96-1.09) compared to low traffic intensity (n = 32, LTL = 1.22, 95%CI 1.13-1.31) [p < 0.001]. In the entire study population, LTL decreased with increasing levels of personal exposure to benzene (p = 0.004) and toluene (p = 0.008). Conclusion: Our results indicate that leukocyte telomere length is shortened in subjects exposed to traffic pollution, suggesting evidence of early biological aging and disease risk.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1476-069X-8-41en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761867/pdf/en_US
dash.licenseLAA
dc.titleAssociation between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Healthen_US
dash.depositing.authorSchwartz, Joel David
dc.date.available2011-05-11T01:40:36Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1186/1476-069X-8-41*
dash.authorsorderedfalse
dash.contributor.affiliatedBaccarelli, Andrea
dash.contributor.affiliatedSchwartz, Joel


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record