dc.contributor.author | Ly, Ngoc P | |
dc.contributor.author | Ruiz-Pérez, Begoña | |
dc.contributor.author | Tzianabos, Arthur O | |
dc.contributor.author | Liang, Catherine | |
dc.contributor.author | Laskey, Daniel | |
dc.contributor.author | DuBois, Andrea M | |
dc.contributor.author | Levy, Hara | |
dc.contributor.author | Celedón, Juan C | |
dc.contributor.author | Onderdonk, Andrew Bruce | |
dc.contributor.author | Litonjua, Augusto Ampil | |
dc.contributor.author | Delaney, Mary Louise Rodriguez | |
dc.contributor.author | Gold, Diane R. | |
dc.contributor.author | Ryan, Louise Marie | |
dc.contributor.author | Weiss, Scott Tillman | |
dc.date.accessioned | 2011-05-15T19:47:01Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Ly, Ngoc P., Begoña Ruiz-Pérez, Andrew B. Onderdonk, Arthur O. Tzianabos, Augusto A. Litonjua, Catherine Liang, Daniel Laskey, et al. 2006. Mode of delivery and cord blood cytokines: a birth cohort study. Clinical and Molecular Allergy 4: 13. | en_US |
dc.identifier.issn | 1476-7961 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889498 | |
dc.description.abstract | Background: The mechanisms for the association between birth by cesarean section and atopy and asthma are largely unknown. Objective: To examine whether cesarean section results in neonatal secretion of cytokines that are associated with increased risk of atopy and/or asthma in childhood. To examine whether the association between mode of delivery and neonatal immune responses is explained by exposure to the maternal gut flora (a marker of the vaginal flora). Methods: CBMCs were isolated from 37 neonates at delivery, and secretion of IL-13, IFN-γ, and IL-10 (at baseline and after stimulation with antigens [dust mite and cat dander allergens, phytohemagglutinin, and lipopolysaccharide]) was quantified by ELISA. Total and specific microbes were quantified in maternal stool. The relation between mode of delivery and cord blood cytokines was examined by linear regression. The relation between maternal stool microbes and cord blood cytokines was examined by Spearman's correlation coefficients. Results: Cesarean section was associated with increased levels of IL-13 and IFN-γ. In multivariate analyses, cesarean section was associated with an increment of 79.4 pg/ml in secretion of IL-13 by CBMCs after stimulation with dust mite allergen (P < 0.001). Among children born by vaginal delivery, gram-positive anaerobes and total anaerobes in maternal stool were positively correlated with levels of IL-10, and gram-negative aerobic bacteria in maternal stool were negatively correlated with levels of IL-13 and IFN-γ. Conclusion: Cesarean section is associated with increased levels of IL-13 and IFN-γ, perhaps because of lack of labor and/or reduced exposure to specific microbes (e.g., gram-positive anaerobes) at birth. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.isversionof | doi:10.1186/1476-7961-4-13 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592116/pdf/ | en_US |
dash.license | LAA | |
dc.title | Mode of Delivery and Cord Blood Cytokines: A Birth Cohort Study | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Clinical and Molecular Allergy | en_US |
dash.depositing.author | Onderdonk, Andrew Bruce | |
dc.date.available | 2011-05-15T19:47:01Z | |
dash.affiliation.other | HMS^Pathology | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Exposure Epidemiology and Risk Program | en_US |
dash.affiliation.other | SPH^Biostatistics | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Molecular+Integrative Physiological Sci Prog | en_US |
dc.identifier.doi | 10.1186/1476-7961-4-13 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Ryan, Louise | |
dash.contributor.affiliated | Delaney, Mary | |
dash.contributor.affiliated | Onderdonk, Andrew | |
dash.contributor.affiliated | Gold, Diane | |
dash.contributor.affiliated | Litonjua, Augusto A. | |
dash.contributor.affiliated | Weiss, Scott | |