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dc.contributor.authorLaden, Francine
dc.contributor.authorNeas, L M
dc.contributor.authorSpiegelman, Donna Lynn
dc.contributor.authorHankinson, Susan Elizabeth
dc.contributor.authorWillett, Walter C.
dc.contributor.authorIreland, K
dc.contributor.authorWolff, Mary S.
dc.contributor.authorHunter, David J.
dc.date.accessioned2011-05-15T19:48:48Z
dc.date.issued1999
dc.identifier.citationLaden, F., L. M. Neas, D. Spiegelman, S. E. Hankinson, W. C. Willett, K. Ireland, M. S. Wolff, and D. J. Hunter. 1999. Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environmental Health Perspectives 107(1): 75-81.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4889499
dc.description.abstractWe evaluated predictors of plasma concentrations of dichlorodiphenyldichloroethylene (DDE), a metabolite of dichlorodiphenyltrichloroethane (DDT), and polychlorinated biphenyls (PCBs) in a group of 240 women, controls from a breast cancer case-control study nested in the Nurses' Health Study. We considered personal attributes such as age, serum cholesterol, region of residence, adiposity, lactation, and dietary intake. DDE levels increased 0.17 ppb/year of age (\(p\) = 0.0003), and PCBs increased 0.08 ppb (\(p\) = 0.0001). DDE and PCBs increased 0.20 (\(p\) = 0.02) and 0.13 ppb (\(p\) = 0.001), respectively, per 10 mg/dl serum cholesterol. Women living in the western United States had higher levels of DDE (mean = 11.0 ppb; \(p\) = 0.003), and women in the Northeast and Midwest had higher levels of PCBs (mean = 5.6 ppb; \(p\) = 0.0002) as compared to women from other parts of the country (mean DDE = 6.3; mean PCBs = 4. 5 ppb). Levels of DDE could not be predicted from consumption of meat, fish, poultry, dairy products, vegetables, fruits, and grains. There was a positive association between fish consumption and PCB concentrations among women in the Northeast and Midwest. Using data from the cases in the nested case-control study to assess the predictive ability of the models, we confirmed that the most reliable predictors of DDE were age and serum cholesterol, and the most important predictors of PCBs were age, serum cholesterol, and residence in the Midwest or Northeast. The null results for the majority of the food variables suggest that specific dietary factors, other than fish, are not currently a substantial contributor to human exposure to DDE and PCBs.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.9910775en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566315/pdf/en_US
dash.licenseLAA
dc.titlePredictors of Plasma Concentrations of DDE and PCBs in a Group of U.S. Women.en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorLaden, Francine
dc.date.available2011-05-15T19:48:48Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Nutritionen_US
dash.affiliation.otherHMS^Ophthalmologyen_US
dc.identifier.doi10.1289/ehp.9910775*
dash.contributor.affiliatedLaden, Francine
dash.contributor.affiliatedWillett, Walter
dash.contributor.affiliatedHunter, David
dash.contributor.affiliatedHankinson, Susan
dash.contributor.affiliatedSpiegelman, Donna


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