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dc.contributor.authorHarari, Raul
dc.contributor.authorJulvez, Jordi
dc.contributor.authorMurata, Katsuyuki
dc.contributor.authorBarr, Dana
dc.contributor.authorBellinger, David C.
dc.contributor.authorDebes, Frodi
dc.contributor.authorGrandjean, Philippe
dc.date.accessioned2011-05-15T21:42:01Z
dc.date.issued2010
dc.identifier.citationHarari, Raul, Jordi Julvez, Katsuyuki Murata, Dana Barr, David C. Bellinger, Frodi Debes, and Philippe Grandjean. 2010. Neurobehavioral Deficits and Increased Blood Pressure in School-Age Children Prenatally Exposed to Pesticides. Environmental Health Perspectives 118(6): 890-896.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4889502
dc.description.abstractBackground: The long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may be vulnerable. Objectives: In northern Ecuador, where floriculture is intensive and relies on female employment, we carried out an intensive cross-sectional study to assess children’s neurobehavioral functions at 6–8 years of age. Methods: We examined all 87 children attending two grades in the local public school with an expanded battery of neurobehavioral tests. Information on pesticide exposure during the index pregnancy was obtained from maternal interview. The children’s current pesticide exposure was assessed from the urinary excretion of organophosphate metabolites and erythrocyte acetylcholine esterase activity. Results: Of 84 eligible participants, 35 were exposed to pesticides during pregnancy via maternal occupational exposure, and 23 had indirect exposure from paternal work. Twenty-two children had detectable current exposure irrespective of their prenatal exposure status. Only children with prenatal exposure from maternal greenhouse work showed consistent deficits after covariate adjustment, which included stunting and socioeconomic variables. Exposure-related deficits were the strongest for motor speed (Finger Tapping Task), motor coordination (Santa Ana Form Board), visuospatial performance (Stanford-Binet Copying Test), and visual memory (Stanford-Binet Copying Recall Test). These associations corresponded to a developmental delay of 1.5–2 years. Prenatal pesticide exposure was also significantly associated with an average increase of 3.6 mmHg in systolic blood pressure and a slight decrease in body mass index of 1.1 kg/m2. Inclusion of the pilot data strengthened these results. Conclusions: These findings support the notion that prenatal exposure to pesticides—at levels not producing adverse health outcomes in the mother—can cause lasting adverse effects on brain development in children. Pesticide exposure therefore may contribute to a “silent pandemic” of developmental neurotoxicity.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0901582en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898869/pdf/en_US
dash.licenseLAA
dc.subjectacetylcholinesteraseen_US
dc.subjectblood pressureen_US
dc.subjectmaternal exposureen_US
dc.subjectneurotoxicity syndromesen_US
dc.subjectoccupational exposureen_US
dc.subjectorganophosphorus compoundsen_US
dc.subjectpesticidesen_US
dc.subjectprenatal exposure delayed effectsen_US
dc.subjectchildren's healthen_US
dc.titleNeurobehavioral Deficits and Increased Blood Pressure in School-Age Children Prenatally Exposed to Pesticidesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorBellinger, David C.
dc.date.available2011-05-15T21:42:01Z
dash.affiliation.otherHMS^Neurology-Children's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.0901582*
dash.contributor.affiliatedGrandjean, Philippe
dash.contributor.affiliatedBellinger, David


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