Residential Exposure to Traffic-Related Air Pollution and Survival after Heart Failure

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Residential Exposure to Traffic-Related Air Pollution and Survival after Heart Failure

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dc.contributor.author Medina-Ramón, Mercedes
dc.contributor.author Goldberg, Robert
dc.contributor.author Melly, Steven John
dc.contributor.author Mittleman, Murray A.
dc.contributor.author Schwartz, Joel David
dc.date.accessioned 2011-05-15T21:52:41Z
dc.date.issued 2008
dc.identifier.citation Medina-Ramón, Mercedes, Robert Goldberg, Steven Melly, Murray A. Mittleman, and Joel Schwartz. 2008. Residential Exposure to Traffic-Related Air Pollution and Survival after Heart Failure. Environmental Health Perspectives 116(4): 481-485. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889508
dc.description.abstract Background: Although patients with heart failure (HF) have been identified as particularly susceptible to the acute effects of air pollution, the effects of long-term exposure to air pollution on patients with this increasingly prevalent disease are largely unknown. Objective: This study was designed to examine the mortality risk associated with residential exposure to traffic-related air pollution among HF patients. Methods: A total of 1,389 patients hospitalized with acute HF in greater Worcester, Massachusetts, during 2000 were followed for survival through December 2005. We used daily traffic within 100 and 300 m of residence as well as the distance from residence to major roadways and to bus routes as proxies for residential exposure to traffic-related air pollution. We assessed mortality risks for each exposure variable using Cox proportional hazards models adjusted for prognostic factors. Results: After the 5-year follow-up, only 334 (24%) subjects were still alive. An interquartile range increase in daily traffic within 100 m of home was associated with a mortality hazard ratio (HR) of 1.15 [95% confidence interval (CI), 1.05–1.25], whereas for traffic within 300 m this association was 1.09 (95% CI, 1.01–1.19). The mortality risk decreased with increasing distance to bus routes (HR = 0.88; 95% CI, 0.81–0.96) and was larger for those living within 100 m of a major roadway or 50 m of a bus route (HR = 1.30; 95% CI, 1.13–1.49). Adjustment for area-based income and educational level slightly attenuated these associations. Conclusions: Residential exposure to traffic-related air pollution increases the mortality risk after hospitalization with acute HF. Reducing exposure to traffic-related emissions may improve the long-term prognosis of HF patients. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.10918 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290984/pdf/ en_US
dash.license LAA
dc.subject air pollution en_US
dc.subject epidemiology en_US
dc.subject follow-up studies en_US
dc.subject heart failure en_US
dc.subject survival en_US
dc.title Residential Exposure to Traffic-Related Air Pollution and Survival after Heart Failure en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Melly, Steven John
dc.date.available 2011-05-15T21:52:41Z
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other SPH^Epidemiology en_US
dash.affiliation.other HMS^Medicine- Beth Israel-Deaconess en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

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