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dc.contributor.authorPuett, Robin C.
dc.contributor.authorYanosky, Jeff D
dc.contributor.authorHart, Jaime Elizabeth
dc.contributor.authorPaciorek, Christopher Joseph
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorSuh MacIntosh, Helen H.
dc.contributor.authorSpeizer, Frank Erwin
dc.contributor.authorLaden, Francine
dc.date.accessioned2011-05-16T23:37:37Z
dc.date.issued2009
dc.identifier.citationPuett, Robin C., Jaime E. Hart, Jeff D. Yanosky, Christopher Paciorek, Joel Schwartz, Helen Suh, Frank E. Speizer, and Francine Laden. 2009. Chronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses' Health Study. Environmental Health Perspectives 117(11): 1702-1706.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4889581
dc.description.abstractBackground: The relationship of fine particulate matter < 2.5 μm in diameter (PM2.5) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particles between 2.5 and 10 μm (PM10–2.5), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles. Objectives: We examined the relationship of chronic PM2.5 and PM10–2.5 exposures with all-cause mortality and fatal and nonfatal incident coronary heart disease (CHD), adjusting for time-varying covariates. Methods: The current study included women from the Nurses’ Health Study living in metropolitan areas of the northeastern and midwestern United States. Follow-up was from 1992 to 2002. We used geographic information systems–based spatial smoothing models to estimate monthly exposures at each participant’s residence. Results: We found increased risk of all-cause mortality [hazard ratio (HR), 1.26; 95% confidence interval (CI), 1.02–1.54] and fatal CHD (HR = 2.02; 95% CI, 1.07–3.78) associated with each 10-μg/m3 increase in annual PM2.5 exposure. The association between fatal CHD and PM10–2.5 was weaker. Conclusions: Our findings contribute to growing evidence that chronic PM2.5 exposure is associated with risk of all-cause and cardiovascular mortality.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0900572en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801178/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectmortalityen_US
dc.subjectparticulate matteren_US
dc.titleChronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses’ Health Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorPaciorek, Christopher Joseph
dc.date.available2011-05-16T23:37:37Z
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Program-EEen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1289/ehp.0900572*
dash.authorsorderedfalse
dash.contributor.affiliatedPaciorek, Christopher Joseph
dash.contributor.affiliatedSuh MacIntosh, Helen H.
dash.contributor.affiliatedSpeizer, Frank
dash.contributor.affiliatedHart, Jaime
dash.contributor.affiliatedLaden, Francine
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2813-2174
dc.identifier.orcid0000-0002-2557-150X


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