Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study

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Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study

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dc.contributor.author Lampe, Brad J.
dc.contributor.author Robins, Thomas
dc.contributor.author Mukherjee, Bhramar
dc.contributor.author Hu, Howard
dc.contributor.author Park, Sung Kyun
dc.contributor.author Litonjua, Augusto Ampil
dc.contributor.author Amarasiriwardena, Chitra J.
dc.contributor.author Weisskopf, Marc G.
dc.contributor.author Sparrow, David
dc.date.accessioned 2011-05-16T23:57:27Z
dc.date.issued 2008
dc.identifier.citation Lampe, Brad J., Sung Kyun Park, Thomas Robins, Bhramar Mukherjee, Augusto A. Litonjua, Chitra Amarasiriwardena, Marc Weisskopf, David Sparrow, and Howard Hu. 2008. Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study. Environmental Health Perspectives 116(9): 1226-1230. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889589
dc.description.abstract Background: High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary function. Objective: In this study we examined the association between pulmonary function and cadmium body burden in a subcohort of the Normative Aging Study, a community-based study of aging. Methods: We examined 96 men who had cadmium measured in single 24-hr urinary specimens collected in 1994–1995 and who had one to three tests of pulmonary function between 1994 and 2002 (a total of 222 observations). We used mixed-effect models to predict pulmonary function based on individual 24-hr urinary cadmium output, adjusted for age, height, time elapsed from the baseline, and smoking status. We assessed effect modification by smoking status. Results: Among all subjects, a single log-unit increase in baseline urinary cadmium was inversely associated with forced expiratory volume in 1 sec (FEV1) percent predicted [β = −7.56%; 95% confidence interval (CI) −13.59% to −1.53%]; forced vital capacity (FVC) percent predicted (β = −2.70%; 95% CI −7.39% to 1.99%), and FEV1/FVC ratio (β = −4.13%; 95% CI −7.61% to −0.66%). In models including an interaction between urinary cadmium and smoking status, there was a graded, statistically significant reduction in FEV1/FVC ratio across smoking status in association with urinary cadmium. Conclusions: This study suggests that chronic cadmium exposure is associated with reduced pulmonary function, and cigarette smoking modifies this association. These results should be interpreted with caution because the sample size is small, and further studies are needed to confirm our findings. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.11265 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535626/pdf/ en_US
dash.license LAA
dc.subject cadmium en_US
dc.subject cigarette smoking en_US
dc.subject forced expiratory volume en_US
dc.subject forced vital capacity en_US
dc.subject pulmonary function en_US
dc.title Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Litonjua, Augusto Ampil
dc.date.available 2011-05-16T23:57:27Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other SPH^Student Stipends en_US

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