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dc.contributor.authorLampe, Brad J.
dc.contributor.authorPark, Sung Kyun
dc.contributor.authorRobins, Thomas
dc.contributor.authorMukherjee, Bhramar
dc.contributor.authorLitonjua, Augusto Ampil
dc.contributor.authorAmarasiriwardena, Chitra J.
dc.contributor.authorWeisskopf, Marc G.
dc.contributor.authorSparrow, David
dc.contributor.authorHu, Howard
dc.date.accessioned2011-05-16T23:57:27Z
dc.date.issued2008
dc.identifier.citationLampe, Brad J., Sung Kyun Park, Thomas Robins, Bhramar Mukherjee, Augusto A. Litonjua, Chitra Amarasiriwardena, Marc Weisskopf, David Sparrow, and Howard Hu. 2008. Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study. Environmental Health Perspectives 116(9): 1226-1230.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4889589
dc.description.abstractBackground: High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary function. Objective: In this study we examined the association between pulmonary function and cadmium body burden in a subcohort of the Normative Aging Study, a community-based study of aging. Methods: We examined 96 men who had cadmium measured in single 24-hr urinary specimens collected in 1994–1995 and who had one to three tests of pulmonary function between 1994 and 2002 (a total of 222 observations). We used mixed-effect models to predict pulmonary function based on individual 24-hr urinary cadmium output, adjusted for age, height, time elapsed from the baseline, and smoking status. We assessed effect modification by smoking status. Results: Among all subjects, a single log-unit increase in baseline urinary cadmium was inversely associated with forced expiratory volume in 1 sec (FEV1) percent predicted [β = −7.56%; 95% confidence interval (CI) −13.59% to −1.53%]; forced vital capacity (FVC) percent predicted (β = −2.70%; 95% CI −7.39% to 1.99%), and FEV1/FVC ratio (β = −4.13%; 95% CI −7.61% to −0.66%). In models including an interaction between urinary cadmium and smoking status, there was a graded, statistically significant reduction in FEV1/FVC ratio across smoking status in association with urinary cadmium. Conclusions: This study suggests that chronic cadmium exposure is associated with reduced pulmonary function, and cigarette smoking modifies this association. These results should be interpreted with caution because the sample size is small, and further studies are needed to confirm our findings.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.11265en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535626/pdf/en_US
dash.licenseLAA
dc.subjectcadmiumen_US
dc.subjectcigarette smokingen_US
dc.subjectforced expiratory volumeen_US
dc.subjectforced vital capacityen_US
dc.subjectpulmonary functionen_US
dc.titleAssociation between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorLitonjua, Augusto Ampil
dc.date.available2011-05-16T23:57:27Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherSPH^Student Stipendsen_US
dc.identifier.doi10.1289/ehp.11265*
dash.contributor.affiliatedAmarasiriwardena, Chitra
dash.contributor.affiliatedWeisskopf, Marc
dash.contributor.affiliatedLitonjua, Augusto A.


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