A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study

DSpace/Manakin Repository

A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study

Citable link to this page

 

 
Title: A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
Author: Asselbergs, Folkert W; Moore, Jason H; van den Berg, Maarten P; de Boer, Rudolf A; Dullaart, Robin P; Navis, Gerjan; van Gilst, Wiek H; Rimm, Eric B.

Note: Order does not necessarily reflect citation order of authors.

Citation: Asselbergs, Folkert W., Jason H. Moore, Maarten P. van den Berg, Eric B. Rimm, Rudolf A. de Boer, Robin P. Dullaart, Gerjan Navis, and Wiek H. van Gilst. 2006. A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study. BMC Medical Genetics 7: 39.
Full Text & Related Files:
Abstract: Background: Studies investigating the genetic and environmental characteristics of atrial fibrillation (AF) may provide new insights in the complex development of AF. We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF. Methods: A nested case-control study within the PREVEND cohort was conducted. Standard 12 lead electrocardiograms were recorded and AF was defined according to Minnesota codes. For every case, an age and gender matched control was selected from the same population (n = 194). In addition to logistic regression analyses, the multifactor-dimensionality reduction (MDR) method and interaction entropy graphs were used for the evaluation of gene-gene and gene-environment interactions. Polymorphisms in genes from the Renin-angiotensin, Bradykinin and CETP systems were included. Results: Subjects with AF had a higher prevalence of electrocardiographic left ventricular hypertrophy, ischemic heart disease, hypertension, renal dysfunction, elevated levels of C-reactive protein (CRP) and increased urinary albumin excretion as compared to controls. The polymorphisms of the Renin-angiotensin system and Bradykinin gene did not show a significant association with AF (p > 0.05). The TaqIB polymorphism of the CETP gene was significantly associated with the presence of AF (p < 0.05). Using the MDR method, the best genotype-phenotype models included the combination of micro- or macroalbuminuria and CETP TaqIB polymorphism, CRP >3 mg/L and CETP TaqIB polymorphism, renal dysfunction and the CETP TaqIB polymorphism, and ischemic heart disease and CETP TaqIB polymorphism (1000 fold permutation testing, P < 0.05). Interaction entropy graph showed that the combination of albuminuria and CETP TaqIB polymorphism removed the most entropy. Conclusion: CETP TaqIB polymorphism is significantly associated with the presence of AF in the context of micro- or macroalbuminuria, elevated C-reactive protein, renal dysfunction, and ischemic heart disease.
Published Version: doi:10.1186/1471-2350-7-39
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462991/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889590
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters