A Systematic Review of Occupational Exposure to Particulate Matter and Cardiovascular Disease

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A Systematic Review of Occupational Exposure to Particulate Matter and Cardiovascular Disease

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dc.contributor.author Cassidy, Adrian
dc.contributor.author Fang, Shona C.
dc.contributor.author Christiani, David C.
dc.date.accessioned 2011-05-17T00:27:02Z
dc.date.issued 2010
dc.identifier.citation Fang, Shona C., Adrian Cassidy, and David C. Christiani. 2010. A Systematic Review of Occupational Exposure to Particulate Matter and Cardiovascular Disease. International Journal of Environmental Research and Public Health 7(4): 1773-1806. en_US
dc.identifier.issn 1661-7827 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889600
dc.description.abstract Exposure to ambient particulate air pollution is a recognized risk factor for cardiovascular disease; however the link between occupational particulate exposures and adverse cardiovascular events is less clear. We conducted a systematic review, including meta-analysis where appropriate, of the epidemiologic association between occupational exposure to particulate matter and cardiovascular disease. Out of 697 articles meeting our initial criteria, 37 articles published from January 1990 to April 2009 (12 mortality; 5 morbidity; and 20 intermediate cardiovascular endpoints) were included. Results suggest a possible association between occupational particulate exposures and ischemic heart disease (IHD) mortality as well as non-fatal myocardial infarction (MI), and stronger evidence of associations with heart rate variability and systemic inflammation, potential intermediates between occupational PM exposure and IHD. In meta-analysis of mortality studies, a significant increase in IHD was observed (meta-IRR = 1.16; 95% CI: 1.06–1.26), however these data were limited by lack of adequate control for smoking and other potential confounders. Further research is needed to better clarify the magnitude of the potential risk of the development and aggravation of IHD associated with short and long-term occupational particulate exposures and to clarify the clinical significance of acute and chronic changes in intermediate cardiovascular outcomes. en_US
dc.language.iso en_US en_US
dc.publisher Molecular Diversity Preservation International (MDPI) en_US
dc.relation.isversionof doi:10.3390/ijerph7041773 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872342/pdf/ en_US
dash.license LAA
dc.subject particles en_US
dc.subject air pollution en_US
dc.subject epidemiology en_US
dc.subject environmental health en_US
dc.subject ischemic heart disease en_US
dc.subject occupation en_US
dc.subject inflammation en_US
dc.subject heart rate variability en_US
dc.subject meta-analysis en_US
dc.title A Systematic Review of Occupational Exposure to Particulate Matter and Cardiovascular Disease en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal International Journal of Environmental Research and Public Health en_US
dash.depositing.author Fang, Shona C.
dc.date.available 2011-05-17T00:27:02Z
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other HMS^Medicine-Massachusetts General Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US

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