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dc.contributor.authorCalafat, Antonia M.
dc.contributor.authorWeuve, Jennifer Lynn
dc.contributor.authorYe, Xiaoyun
dc.contributor.authorJia, Lily T.
dc.contributor.authorHu, Howard
dc.contributor.authorRinger, Steven Alan
dc.contributor.authorHuttner, Ken
dc.contributor.authorHauser, Russ B.
dc.date.accessioned2011-05-18T23:16:31Z
dc.date.issued2008
dc.identifier.citationCalafat, Antonia M., Jennifer Weuve, Xiaoyun Ye, Lily T. Jia, Howard Hu, Steven Ringer, Ken Huttner, and Russ Hauser. 2009. Exposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants. Environmental Health Perspectives 117(4): 639-644.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4891651
dc.description.abstractObjective: We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites in 54 premature infants in two neonatal intensive care units than in the general population. For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices. Measurements: We measured the urinary concentrations of free and total (free plus conjugated) species of BPA, triclosan, benzophenone-3, methyl paraben, and propyl paraben. Results: The percentage of BPA present as its conjugated species was > 90% in more than three-quarters of the premature infants. Intensity of use of products containing DEHP was strongly associated with BPA total concentrations but not with any other phenol. Adjusting for institution and sex, BPA total concentrations among infants in the group of high use of DEHP-containing products were 8.75 times as high as among infants in the low use group (p < 0.0001). Similarly, after adjusting for sex and DEHP-containing product use category, BPA total concentrations among infants in Institution A were 16.6 times as high as those among infants in Institution B (p < 0.0001). Conclusion: BPA geometric mean urinary concentration (30.3 μg/L) among premature infants undergoing intensive therapeutic medical interventions was one order of magnitude higher than that among the general population. Conjugated species were the primary urinary metabolites of BPA, suggesting that premature infants have some capacity to metabolize BPA. The differences in exposure to BPA by intensity of use of DEHP-containing medical products highlight the need for further studies to determine the specific source(s) of exposure to BPA.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0800265en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679610/pdf/en_US
dash.licenseLAA
dc.subjectbenzophenoneen_US
dc.subjectBPAen_US
dc.subjectbiomonitoringen_US
dc.subjectglucuronidationen_US
dc.subjectneonateen_US
dc.subjectNICUen_US
dc.subjectparabenen_US
dc.subjecttriclosanen_US
dc.subjectchildren's healthen_US
dc.titleExposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infantsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorWeuve, Jennifer Lynn
dc.date.available2011-05-18T23:16:31Z
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dash.affiliation.otherHMS^Obstetrics Gynecology and Repro. Bio. - MGHen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.0800265*
dash.contributor.affiliatedWeuve, Jennifer Lynn
dash.contributor.affiliatedHauser, Russ
dash.contributor.affiliatedRinger, Steven


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